ABSTRACT
We report an oriental family with sex-linked mental retardation, macroorchidism, and a marker or fragile site on the X chromosome--mar(X)(q28). The three affected males resemble clinically most previously reported affected Caucasians. The marker was present in four female 40-70 years old, including one with normal intelligence. Transmission of the disorder appears to have taken place through a clinically normal male to his grandson.
Subject(s)
Chromosome Fragility , Intellectual Disability/genetics , Sex Chromosome Aberrations/genetics , Adolescent , Adult , Aged , Chromosome Fragile Sites , Female , Humans , Male , Middle Aged , Pedigree , Syndrome , Testis/abnormalities , X ChromosomeABSTRACT
In a study of the use of General Revenue Sharing (GRS) funds by the states and by cities of 100,000 and over in the United States for fiscal years 1973 and 1974, we found that few states and large cities allocated or requested GRS funds for Maternal and Child Health (MCH), Crippled Children (CC), and related services. One third of the states and cities reported suggestions for use of GRS funds for MCH, CC, and related services.
Subject(s)
Child Health Services , Financing, Government , Maternal Health Services , Child , Female , Humans , United StatesSubject(s)
Attitude of Health Personnel , Child Abuse , Education, Medical, Continuing , Physicians , Child, Preschool , Humans , Infant , Pediatrics , Radiology , Social Control, FormalABSTRACT
The California Project of the Inter-American Investigation of Mortality in Childhood was carried out in San Francisco and three surrounding counties in 1969 and 1970. The study found infant death rates of 18.5 per 1,000 live births in San Francisco and 17.2 per 1,000 live births in the three counties. Mortality in the neonatal period (the first 28 days of life) accounted for two-thirds of these deaths. Low birth-weitht played a key role in neonatal mortality, one that was particularly marked during the first day of life. Overall, the study found that 77.7 per cent of the neonatal fatalities and 85.6 percent of those dying in the first day of life weighed 2,500 grams or less at birth. Mortality was also very high among infants of mothers under 20 and over 34 years of age., the risks being especially great in the case of young mothers. Moreover, the vast majority of babies that were born to young mothers and died the first day had very low birth-weights. It is therefore concluded that young mothers ran a relatively high risk of having low birth weight babies prone to dying in the first day of life. This demonstrates a clear need for special measures capable of reducing the health risk faced by both young mothers and their children. Besides providing a more detailed explanation of these points, the authors recommend various specific measures that should be taken and present data obtained by the California Project on other aspects of mortality among infants and preschool children 1-4 years of age
