[The role of proteolytic enzymes and their inhibitors in malignant neoplasm invasion (literature review)]. / Rol' proteoliticheskikh fermentov i ikh ingibitorov v invazii zlokachestvennykh opukholei (obzor literatury).

Putative mechanisms by which proteinases and their inhibitors participate in tumour invasion and possible involvement of proteinase inhibitors in tumour growth regulation are considered. The significance of proteinases and their inhibitors for diagnosis of cancer is evaluated.

[Specific proteinase plasma sorption in surgery with artificial blood circulation]. / Spetsificheskaia plazmosorbtsiia proteinaz pri operatsiiakh s isskustvennym krovoobrashcheniem.

Cardiosurgery with artificial circulation (AC) is attended with activation of plasma cascade proteolytic systems, which leads to homeostatic disturbances and postoperative complications. AC with the use of specific proteinase plasma sorption in a column with sepharose-immobilized acid-base proteinase inhibitor from human urine prevents activation of proteinase in the plasma. Application of specific plasma sorption facilitates rapid restoration of the plasma protein concentration lowered during AC, improves the course of the postoperative period, and reduces the risk of pulmonary, cardiovascular, and nervous complications.