[Correlation between immunoglobulin-secreting cells and secretory immunoglobulins in the small intestine in chronic intestinal diseases]. / Korelatsiia mezhdu imunoglobulin-sekretirashtite kletki i sekretornite imunoglobulini v tunkite cherva pri niakoi khronichni chrevni zaboliavaniia.

A total of 45 patients were studied: seven with gluten enteropathy and 38 with chronic unspecific enteritis. Histological and immunefluorescent studies were performed and to a part of the cases--enzymatic and electron-microscopic investigations of the jejunal mucosa. An increased number of immuneglobulin -secreting cells was established in the non-treated patients with gluten enteropathy, growing with age. In the cases with chronic unspecific enteritis with a manifested clinic, a tendency to decrease of the number of IgSC was observed, with growing percentage of IgG-SC and the values of the secretory IgG. There was no correlation between the intraepithelially located lymphocytes and those in the chorion, as well as between the duration of the disease, number and percentage distribution of Ig-SC.

[Significance of high titers of various autoantibodies in the diagnosis and monitoring of chronic liver diseases]. / Znachenie na visokite titri na niakoi avtoantitela za diagnostikata i proslediavaneto na khronichnite chernodrobni zaboliavaniia.

The diagnostic value of the high antibody titres are assessed in the work--namely antinuclear, antimitochondrial and antismooth-muscular, in chronic liver diseases. For that purpose 220 patients with morphologically confirmed chronic hepatitis and chronic liver cirrhosis were examined. Twenty three of them proved to have high titre antibodies. It was established that the females predominated in that group--20 out of 23. The high titre of autoantibodies correlated with the morphological data for the activity of the liver injury. No connection was established with the presence or absence of HB-virus markers in the cases with high titres of ASMA. HB-virus markers were found in none of the eight patients with high titres AMA. One of the six patients with high titres ANA had HBs-antigenemia. In the patients with high titres of autoantibodies, hyperimmunoglobulinemia, class IgG was most often established, whereas IgA and IgM were found almost with the same incidence in normal and elevated values. There were enzymologic data about hepatocytolysis and cholestasis in the majority of the cases. ASMA titre decreased in parallel with the decrease of the activity of the morbid process under the treatment effect.

[Circulation immune complexes in chronic glomerulonephritis]. / Tsirkulirashti imunni kompleksi pri bolni s khronichni glomerulonefriti.

Thirty six patients with chronic glomerulonephritis, 35 -- with chronic pyelonephritis, 5 -- with diffuse glomerulonephritis with systemic lupus erythematosus and 60 healthy subjects were examined with the method by sedimentation with 3.5 per cent solution of polyethyleneglycol for the determination of circulating immune complexes. The average value for the healthy subjects is X = 0.123 +/- 0.047 mg/ml. The average value plus two standard deviations = 0.217 mg/ml is accepted as normal in healthy subjects. An elevated level of circulating immune complexes is found in 60 per cent of the patients with lupus nephritis and 25 per cent of the patients with chronic glomerulonephritis. The average values for the last two groups are X = 0.475 +/- 0.554 mg/ml and X = 0.184 +/- 0.185 mg/ml respectively. Whereas in the patients with lupus nephritis the values for the single patients are considerably over the adopted norm, in patients with chronic glomerulonephritis, in the majority of the cases, they are about its upper limit.

[Immunological indices in chronic liver diseases]. / Imunologichni pokazateli pri bolni s khronichni chernodrobni zaboliavaniia.

The study aimed at the confrontation of the results from the investigation of the immunoglobulines G, M, and A (IgG, IgM and IgA), the test for spontaneous rosette formation and the determination of Australian antigen (HBsAg) in 110 patients with chronic liver disease (liver steatosis, chronic persisting hepatitis, chronic aggressive hepatitis and liver cirrhosis). The diagnosis was morphologically confirmed and some of the patients were repeatedly examined. No significant interrelations among the three main classes of immunoglobulines were established in the majority of the groups of chronic liver diseases, speaking for the individual information, carried by the separate immunoglobuline classes. Correlation was established between IgG and IgM in chronic active hepatitis. The mean values of IgG and IgM are considerably higher in cases with splenomegaly. IgG is more often increased when the patients are carriers of HBsAg, being in agreement with the contemporary concepts about the differences in immune pathological mechanism in chronic liver diseases, with and without HB5-antigenemia.

[Immunological studies of patients with chronic ulcerative-hemorrhagic colitis]. / Imunologichni izsledvaniia pri bolni s khronichen ultsero-khemoragichen kolit

Immunologic investigations were carried out with 22 patients with chornic ulcerohemorrhagic colitis in the course of three years. The average values of IgA and TSRFC in the active stage of the disease surpass significantly the normal values. They, to a very large degree, can contribute to the assessment of an advancing remission and in the course of an immunosuppressive treatment the decrease of the therapeutic dosage and the extent to which the patients keep to the prescribed scheme are taken in consideration for its inclusion.

[Immunoglobulins in the gastric juice in some stomach and duodenal diseases]. / Imunoglobulini v stomashniia sok pri niakoi stomashni i duodenalni zaboliavaniia

IgA, IgM and IgC content in blood serum and gastric juice were determined in 89 patients with different gastric and duodenal diseases (57 with duodenal ulcers, 13 with gastric ulcers 8 with chronic atrophic gastritis, 9 with superficial chronic gastritis and gastroduodenitis and two with gastric cancer). Immunoglobulin was established in gastric juice (over 0,3 mg/100 ml) in 49 per cent of all the patients examined with gastric and duodenal diseases. No correlation was found between serum immunoglobulin level and their presence in the gastric juice. No correlation exists between the volume of the basal secretion and the presence or absence of immunoglobulins in the gastric juice. Immunoglobulins were established more often in the gastric juice with lower secretion of hydrochloric acid (in chronic atrophic gastritis and gastric ulcer), while in cases of higher secretion they are more frequently absent. A certain parallelism was established between the changes of hydrochloric acid output and JgA secretion in the gastric juice after stimulation of gastric secretion by Pentagastrin or histamine.