COVID-19 induced shocks and its implications for human capital development.

BACKGROUND: COVID-19 has delivered an enormous shock to the global economy, triggering the deepest recession in eight decades, almost three times as deep as the 2009 global recession. Of all the nations in Africa, Nigeria remains one of the nations with a huge and significant impact on the human capital. METHODS: Hence, here we employed the recent nationally representative data from Nigeria - the COVID-19 National Longitudinal Phone Survey 2020-World Bank Living Standards Measurement Study Integrated Agriculture Survey (LSMS-ISA), a harmonized dataset to explore how the COVID-19 induced shocks affected households' human capital development (using health and education outcomes). RESULTS: The results indicate that the COVID-19 induced shocks impact on both health and education in Nigeria. Interestingly, access to social safety nets had a positive association with the health and education outcomes. The study concludes that households' access to social safety nets, particularly during the COVID-19 pandemic aids in the development of the nation's human capital. Therefore, effectively enhancing household's resilience and strengthening human capital development require positive and considerable innovation, maybe over a period of years. Hence, just an access to the national social safety nets programs or social programs may not be as effective as expected. Therefore, it may not be as successful as intended to just have access to national social safety net programs or social programs that contribute or transfer negligible amounts to the vulnerable recipients over short time frames.

Do soil and water conservation practices influence crop productivity and household welfare? Evidence from rural Nigeria.

One of the most serious challenges threatening agricultural sustainability in Nigeria is land degradation. Although this issue has received little attention, soil and water conservation practices have been identified as a possible pathway out of the potential problems posed by land degradation. Therefore, the central research question that this paper tries to address is the following: Do adoption of soil and water conservation (SWC) practices affect crop productivity and household welfare? This paper uses data collected by the International Institute of Tropical Agriculture (IITA) from maize farmers in rural Nigeria. We usedemploy the propensity score matching (PSM), inverse probability weighting adjusted regression model (IPWRA) approach, and the linear regression with endogenous treatment effect (LRETE) model to incorporate the typologies of SWC practices, and tested how the model affects crop productivity and household welfare. Additionally, multinomial logit was used to estimate the factors influencing the decision to adopt single and multiple SWC practices. The estimates show that education, age of the household head, access to credit, experience of drought, soil fertility, and occupational stress contribute to the decision to adopt SWC practices. The casual effect estimates reveal that both single and multiple adoptions of SWC practices had a positive and significant relationship with the crop productivity and welfare of the adopters. The results show that the adoption of combined SWC practices has a higher impact on crop productivity and welfare than single SWC practices. For instance, the adoption of a combination of three SWC practices was found to increase crop productivity and household welfare by 27.55% and 38.23%, respectively versus 13.91% and 15.11% in the case of single SWC practices. The study suggests that profile-raising agenda and efforts that focus on promoting the adoption of combination of SWC practices should be designed and implemented to enhance crop productivity and hence the welfare of the maize farming households in rural Nigeria.

Assessing food security among young farmers in Africa: evidence from Kenya, Nigeria, and Uganda.

Food insecurity remains a serious challenge for many households in Africa and the situation is even more prevalent among young people. However, there is a dearth of empirical evidence on youth food security status in Africa. We assessed the level and determinants of food security among young farmers in Africa. We adopted a multi-stage sampling technique to select 400, 429, and 606 young farmers in Kenya, Nigeria, and Uganda, respectively. Individual food consumption was assessed following a 7 days recall method. The Food Consumption Score, which combines dietary diversity and consumption frequency was used to assess food security status while the determinants of food security were identified using a logistic regression model. Results suggest low dietary diversity across the three countries. Also, the majority of the respondents had an unacceptable food consumption score, suggesting that despite being food producers, young farmers are still food insecure. The odds of being food secure was positively determined by access to extension services, participation in the ENABLE TAAT business incubation programme, and access to market information but, negatively by access to credit, number of employees, Covid-19 pandemic, and location. Additionally, the food security status of young female farmers was positively influenced by age, suggesting that younger youths are less food secure compared to older ones. These results suggest that more efforts should be directed towards improving the food security of young African farmers and that policy- and programme-level interventions should support access to extension services, market information, and land. Additionally, more investments should be directed towards developing need-based agribusiness incubation programmes with an effort to scale existing programmes beyond the regular one-time period.

COVID-19, food insecurity and dietary diversity of households: Survey evidence from Nigeria.

The policy measures of the government of Nigeria to restrain the spread of COVID-19, particularly in the initial three months (April - June 2020) led to significant disruptions to household livelihoods and food security. We investigate the effects of COVID-19 on food security and dietary diversity of households; focusing on the pathways through which income loss, endowments of wealth, social capital, and safety net programs moderate the severity of households' food security and dietary diversity. Primary data obtained from a telephone survey of 1,031 Nigerian households were analyzed using ordered logit and negative binomial models. Our results show that income losses due to the COVID-19 restrictive measures had pushed households into a more severe food insecurity and less diverse nutritional outcomes. Regarding wealth effects, livestock ownership significantly cushioned households from falling into a more severe food insecurity amid the pandemic. We found that because of the pandemic's indiscriminate effect across communities, the potential of social capital as an informal support mechanism might have been eroded to enable households to cope with shocks. Furthermore, safety net programs by the government and NGOs did not provide significant protection to households from falling into severe food insecurity and malnutrition amid the pandemic. We suggest three policy propositions - prioritize investment in local job creation to curb income loss; build the wealth base of households (e.g., land tenure security or livestock) to enhance resilience to shocks; and target safety nets and other social support programs spatially, temporally, and across social groups to enhance the effectiveness of such programs amid shocks.

Disentangling Drivers of Food Waste in Households: Evidence from Nigeria.

Food waste is a burden on society in terms of the money wasted. There is limited information on the determinants of food waste and the amount lost to food waste by households as most previous studies were on post-harvest losses. Hence, determinants of food waste among households in Kogi West Senatorial District, Kogi State Nigeria were investigated. A three-stage sampling technique was used to select the respondents, while a structured questionnaire was used for data collection. Data were analyzed using Tobit regression and an equality test. The study revealed that food waste was higher in male headed households. The average monthly food waste proportion among urban households was significantly higher than that of rural households. The estimated amounts lost to food waste per month were ₦2103 and ₦5530 for the rural and urban households, respectively. These represented 7.2% and 13.1% of the total expenditure on food per month for rural and urban households, respectively. Among rural households, leftovers of food and lack of proper storage were the main reasons for food waste, while leftovers of food and preparation of food more than needed were the reasons for food waste among urban households. The sex of respondents, work experience, and monthly income influenced the proportion of food waste among rural households, while the dependency ratio, monthly income, and monthly food expenditure were the determinants of proportion of food waste among the urban households. Non-Governmental Organization efforts through sensitization campaigns focused on the need to reduce food waste, especially among urban households, would help to reduce the financial burden of food waste on households.

Clean water, sanitation and under-five children diarrhea incidence: Empirical evidence from the South Africa's General Household Survey.

Sufficient supply of potable water, hygiene facilities, and sanitation are major factors enhancing healthy living. Using the dataset from the 2018 South Africa General Household Survey, this study employed the logistic regression model to examine the effects of accessibility to potable water and sanitation on the incidence of diarrhea among under-five children. The findings from the research reveal that the majority of children have access to safe drinking water, although a substantial percentage (32%) of the households had to pay for access. The results of the logistic regression model show that households with access to clean water, to improved toilet facilities, and to water within their residence are less likely to record incidence of diarrhea among under-five children. Moreso, the likelihood of reporting diarrhea among the children decreases with the age of children and the age of household heads. Therefore, to contribute to the designing policies targeted at reducing the incidence of diarrhea among children, this study emphasized that the availability and accessibility of clean water, water-storage facilities, and improved fecal discharge facilities among the South African households are key.

Does economic shocks influence household's healthcare expenditure? Evidence from rural Nigeria.

Health is profoundly influenced by several factors outside the traditional realm of healthcare. This paper employed a two-step Heckman selectivity model to examine factors influencing the decision to spend on health and the effects of economic shocks on health expenditure. The results from the first stage shows that the likelihood of spending on health increased with age, education, income, and decreases if the household is living in the northern region of Nigeria and uses mosquito bed-net. The findings from the second stage estimation show that a fall in the price of food items, an increase in the price of inputs for household enterprises and loss of job are the significant shocks that affect household health expenditure. Based on these findings, this study concluded that fall in the prices of major food items consumed within the household increased income available for health care among the farmers. Going forward, the study recommends the provision of holistic health-economic-welfare interventions for the marginalized rural populace in Nigeria.

Does agricultural cooperative membership impact technical efficiency of maize production in Nigeria: An analysis correcting for biases from observed and unobserved attributes.

The formation of agricultural cooperatives has been widely promoted as an agricultural development policy initiative to help smallholder farmers cope with multiple production and marketing challenges. Using a nationally representative survey dataset of smallholder maize producers from rural Nigeria, this study assesses the impact of agricultural cooperative membership on technical efficiency (TE). We based our estimation approach on the combination of a newly developed sample selection stochastic production frontier model with propensity score matching to control for possible selectivity biases from both observables and unobservables. We estimate stochastic meta-frontiers to examine TE differences between cooperative members and non-members. Our results reveal that TE levels of members are consistently higher than that of non-members. This calls for continued policy incentives targeted at encouraging farmers to form as well as participate in agricultural cooperatives.

Exploring the Resource Value of Transvaal Red Milk Wood (Mimusops zeyheri) for Food Security and Sustainability: An Appraisal of Existing Evidence.

Many African countries are endowed with rich biodiversity with enormous nutritional and economic prospects, but the majority of these resources are not fully harnessed. Exploring these neglected resources, for example, the Transvaal red milkwood tree [(Mimusops zeyheri) Sond. family: Sapotaceae] is of paramount importance for food and nutritional security as well as economic prosperity. This review provides a critical appraisal of the nutritional and health benefits as well as the economic potential of Mimusops zeyheri. The plant is known for its diverse uses among rural communities. In folk medicine, the decoction from the bark and leaves of Mimusops zeyheri are used for treating wounds and ulcers, while the root is used as an infusion taken to treat candidiasis and other health issues. The nutritional profile of the fruit tree is similar to popular exotic fruits and richer in vitamin C when compared to guava and orange. Mimusops zeyheri is a rich source of vitamins, protein, and fatty acids. Based on the rich chemical pool, especially in the fruit and seeds, it has the potential to provide an accessible, readily available, and affordable enriched functional food with valuable health benefits. However, the successful exploration of Mimusopszeyheri for food security and sustainability requires multidisciplinary research. This will help achieve the envisaged food-nutrition security and poverty alleviation potential of the plant, especially among local communities.

What Drives Households' Payment for Waste Disposal and Recycling Behaviours? Empirical Evidence from South Africa's General Household Survey.

Safeguarding the environment and its citizens' health remains one of the key policy priorities of the governments of many developing and emerging countries. Using the 2017 General Household Survey (GHS) dataset, this study examines the driving factors affecting households' recycling behaviour and payment for waste disposal in South Africa. The methods of data analysis were based on descriptive statistics and a Bivariate Probit regression model. The descriptive statistics results indicate that there are 56.29% male-headed and 43.71% female headed households, with an average age of 49 years. In addition, the study shows that 89.97% of household heads had formal education with a mean monthly income of 11,099.07 ZAR/650.504 USD. The study also revealed that 22% of the households sampled had access to social grants. The results from the Bivariate Probit regression model show that household's income, access to social grants, formal educational attainment and the age of the household were significant (p < 0.01) driving factors affecting households' recycling behaviour and payment for waste disposal. The study concludes that the households' socio-economic factors affect their recycling behaviour and willingness to pay for waste management in South Africa. Actions targeted at poverty alleviation and environmental sensitization programmes are key for facilitating environmental conservation behaviours of households in South Africa in order to achieve the environmental sustainability Sustainable Development Goal (SDG) target of the United Nations.

Data on food insufficiency status in South Africa: Insight from the South Africa General Household Survey.

Food insecurity or insufficiency, among other factors, is triggered by structural inequalities. Food insecurity is an inflexible problematic situation in South Africa. The country has a custom of evidence-based decision making, stocked in the findings of generalized national household surveys. Conversely, the deep insights from the heterogeneity of the sub-national analysis remain a principally unexploited means of understanding of the contextual experience of food insecurity or insufficiency in South Africa. The data present the food insufficiency status with special focus on adult and children. The data also reveal the adult and children food insufficiency status across the provinces in South Africa. The data contains socioeconomic and demographic characteristics as well the living condition and food security status of the households.

Correction: Mother's nutrition-related knowledge and child nutrition outcomes: Empirical evidence from Nigeria.

[This corrects the article DOI: 10.1371/journal.pone.0212775.].

Mother's nutrition-related knowledge and child nutrition outcomes: Empirical evidence from Nigeria.

BACKGROUND: Nutrition outcomes among young children in Nigeria are among the worse globally. Mother's limited knowledge about food choices, feeding, and health care seeking practices contributes significantly to negative nutrition outcomes for children in most developing countries. Much less is known about the relationship between mother's nutrition-related knowledge and child nutritional outcomes in rural Nigeria. This paper investigates therefore: (i) the association of mother's nutrition-related knowledge with nutrition outcomes of young children living in rural Nigeria, where access to education is limited, and (ii) whether mother's education has a complementary effect on such knowledge in producing positive child nutrition outcomes in such settings. METHODS: Using the Demographic and Health Survey data for Nigeria, we employ both descriptive and regression analyses approaches in analyzing the study's objectives. In particular, we apply ordinary least square (OLS) to investigate the association of mother's nutrition-related knowledge with child HAZ and WHZ while controlling for maternal, child, household and regional characteristics. An index was constructed for mother's nutrition-related knowledge using information on dietary practices, disease treatment and prevention, child immunization, and family planning. RESULTS: We found that mother's knowledge is independently and positively associated with HAZ and WHZ scores in young children. Higher levels of mother's education, typically above primary, have a significant, positive association with child HAZ and WHZ scores. We argue that mother's knowledge of health and nutrition may substitute for education in reducing undernutrition in young children among populations with limited access to formal education. However, the present level of mother's education in rural Nigeria appears insufficient to reinforce knowledge in producing better nutrition outcomes for children. CONCLUSIONS: This study suggests promotion of out-of-school (informal) education, such as adult literacy and numeracy classes where women without formal education can gain health and nutrition knowledge, and practices that could enhance child nutrition outcomes in Nigeria.

New Food and Drug Administration-Approved and Emerging Novel Treatment Options for Acute Myeloid Leukemia.

Advancements in the treatment of acute myeloid leukemia (AML) have been sparse during the past several decades, and the disease continues to have a poor prognosis. However, in 2017 alone, four new medications approved by the U.S. Food and Drug Administration (FDA) for the treatment of AML reached the market. Midostaurin, liposomal cytarabine and daunorubicin, enasidenib, and gemtuzumab ogozamicin all showed benefit in respective clinical trials to gain approval for the treatment of AML in various patient populations. Additionally, many phase II and III clinical trials are currently ongoing to assess the safety and efficacy of other potential therapies for the treatment of AML. In this review, we summarize the results of the landmark clinical trials associated with the newly approved agents as well as the current ongoing clinical trials for the treatment of AML. A literature search was performed to retrieve data on agents currently being studied for use. Although the overall prognosis for patients with AML remains poor, the addition of the newly FDA-approved medications is a step in the right direction for a disease state that has proved difficult to treat.

The ABCs of Immunotherapy for Adult Patients With B-Cell Acute Lymphoblastic Leukemia.

OBJECTIVE: To review the pharmacology, efficacy, and safety of Food and Drug Administration approved and promising immunotherapy agents used in the treatment of acute lymphoblastic leukemia (ALL). DATA SOURCES: A literature search was performed of PubMed and MEDLINE databases (1950 to July 2017) and of abstracts from the American Society of Hematology and the American Society of Clinical Oncology. Searches were performed utilizing the following key terms: rituximab, blinatumomab, inotuzumab, ofatumumab, obinutuzumab, Blincyto, Rituxan, Gazyva, Arzerra, CAR T-cell, and chimeric antigen receptor (CAR). STUDY SELECTION/DATA EXTRACTION: Studies of pharmacology, clinical efficacy, and safety of rituximab, ofatumumab, obinutuzumab, inotuzumab, blinatumomab, and CAR T-cells in the treatment of adult patients with ALL were identified. DATA SYNTHESIS: Conventional chemotherapy has been the mainstay in the treatment of ALL, producing cure rates of approximately 90% in pediatrics, but it remains suboptimal in adult patients. As such, more effective consolidative modalities and novel therapies for relapsed/refractory disease are needed for adult patients with ALL. In recent years, anti-CD20 antibodies, blinatumomab, inotuzumab, and CD19-targeted CAR T-cells have drastically changed the treatment landscape of B-cell ALL. CONCLUSION: Outcomes of patients with relapsed disease are improving thanks to new therapies such as blinatumomab, inotuzumab, and CAR T-cells. Although the efficacy of these therapies is impressive, they are not without toxicity, both physical and financial. The optimal sequencing of these therapies still remains a question.

Upfront use of plerixafor and granulocyte-colony stimulating factor (GCSF) for stem cell mobilization in patients with multiple myeloma: efficacy and analysis of risk factors associated with poor stem cell collection efficiency.

Plerixafor (P), an agent that selectively and reversibly binds to the chemokine receptor CXCR4, has been approved in combination with G-CSF (P + G-CSF) for stem cell (SC) mobilization in patients with multiple myeloma (MM). The goal of this study was to determine the SC collection success rate of P + G-CSF using a clinically relevant outcome defined as the ability to collect at least 5 × 106 CD34+ cells/kg to allow safely two transplants, and identify risk factors impacting SC mobilization. One hundred and thirty-eight patients were mobilized with P + G-CSF upfront following induction. The SC collection success rate was 92.8%. We identified exposure to lenalidomide alone (p = .038), WBC count <4 × 103/mcL prior to mobilization (p = .01) and non-African American race (p = .019), as risk factors for low efficiency by multivariate analysis. This study demonstrates that P + G-CSF is highly efficient in MM patients and provides strong support for its upfront use in SC collection for MM patients.

Pembrolizumab for the treatment of PD-L1 positive advanced or metastatic non-small cell lung cancer.

The emergence of immune checkpoint inhibitors marked an important advancement in the development of cancer therapeutics. Pembrolizumab is a selective humanized IgG4 kappa monoclonal antibody that inhibits the programmed death-1 (PD-1) receptor, an integral component of immune checkpoint regulation in the tumor microenvironment. The drug is currently approved by the Food and Drug Administration for the treatment of advanced melanoma and metastatic squamous and nonsquamous non-small cell lung cancer (NSCLC). Several published studies demonstrate that single-agent pembrolizumab is safe and has efficacy in patients with NSCLC. Many ongoing protocols are investigating the role of pembrolizumab in combination with other agents in lung cancer and various other cancer types. We review the available data on pembrolizumab in NSCLC and examine the role of potential predictive biomarkers of response to therapy.

Current status and future directions of the immune checkpoint inhibitors ipilimumab, pembrolizumab, and nivolumab in oncology.

OBJECTIVE: To provide the clinician with an update and the current status and future direction of approved immune checkpoint inhibitors (ICIs) in oncology. DATA SOURCES: A PubMed search from January 1, 1966 to March 13, 2015 was performed using the key terms ipilimumab, pembrolizumab, lambrolizumab, nivolumab, immune checkpoint inhibitor, MDX-010, MDX-101, BMS-734016, MK-3475, SCH 900475, MDX-1106, BMS-936558, ONO-4538, CTLA-4, PD-1, or PD-L1 and cancer, oncology, or neoplasm. Additional references were identified from the investigators(') personal files, recent oncology meetings, review articles, clinical guidelines, and package inserts. STUDY SELECTION AND DATA EXTRACTION: All English-language clinical trials assessing the safety and efficacy of ipilimumab, nivolumab, and pembrolizumab in cancer were considered. The PubMed search resulted in 215 trials; 33 met inclusion criteria. A further 28 trials were identified from the above sources; 61 trials from 2005 to 2015 were included. We consolidated and clarified treatment recommendations for the management of immune-related adverse events (irAEs), assessed response criteria, and calculated the clinical utility of leading tumor profiling options. DATA SYNTHESIS: Ipilimumab and nivolumab, but not pembrolizumab, have an overall survival (OS) advantage over chemotherapy first line in unresectable/metastatic melanoma. Nivolumab has an OS advantage versus chemotherapy in second-line squamous non-small-cell lung cancer. Data in other settings are promising. Nivolumab and pembrolizumab are better tolerated than ipilimumab. Further validation of response criteria is needed. Tumor profiling to predict clinical benefit is premature but promising. CONCLUSIONS: The treatment landscape in oncology is quickly evolving with the advent of ICIs.