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Cyanopeptoline CB071: a cyclic depsipeptide isolated from the freshwater cyanobacterium Aphanocapsa sp.
Choi, Hyukjae; Oh, Sun Kwan; Yih, Wonho; Chin, Jungwook; Kang, Heonjoong; Rho, Jung-Rae.
Chem Pharm Bull (Tokyo) ; 56(8): 1191-3, 2008 Aug.
Article in English | MEDLINE | ID: mdl-18670126

ABSTRACT

Cyanopeptolin CB071 (1), a trypsin inhibitor, was isolated from the freshwater cyanobacterium Aphanocapsa sp. Its complete structure was determined by detailed NMR spectroscopy and MS analyses, along with chemical reactions. The compound showed inhibition of trypsin at a concentration of IC50=2.5 microM.


Subject(s)
Cyanobacteria/chemistry , Depsipeptides/isolation & purification , Depsipeptides/chemistry , Depsipeptides/pharmacology , Fresh Water/microbiology , Molecular Structure , Trypsin Inhibitors/chemistry , Trypsin Inhibitors/isolation & purification , Trypsin Inhibitors/pharmacology
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