1.
Biosci Biotechnol Biochem
; 86(11): 1570-1575, 2022 Oct 20.
Article
in English
| MEDLINE
| ID: mdl-36130217
ABSTRACT
This study reports that black rice bran (BRB) intake for 50-52 consecutive weeks (â¼12 months) reduces tau phosphorylation with a concomitant activation of insulin signaling and subsequent PI3K/AKT pathway in the brain of aged normal mice. BRB holds promise for preventing the formation of neurofibrillary tangles consisting of hyperphosphorylated tau, a pathological hallmark of Alzheimer's disease.