ABSTRACT
The propofol infusion syndrome is a rare but potentially lethal complication resulting from a prolonged continuous administration of propofol. It was first described in the beginning of the 1990's and in recent years there have been frequent reports of problems in association with the use of propofol sedation. The cardinal signs and symptoms of the propofol infusion syndrome are metabolic acidosis, rhabdomyolysis, renal failure, cardiac arrhythmias and a progressive, often therapy-resistant cardiac failure. The pathophysiology of this syndrome appears to involve a disturbance of mitochondrial metabolism induced by propofol. Our report involves a case of propofol infusion syndrome in a patient having undergone cardiac surgery.
Subject(s)
Acidosis/chemically induced , Acute Kidney Injury/chemically induced , Anesthesia, Intravenous/adverse effects , Anesthetics, Intravenous/adverse effects , Arrhythmias, Cardiac/chemically induced , Intraoperative Complications/chemically induced , Propofol/adverse effects , Rhabdomyolysis/chemically induced , Acidosis/diagnosis , Acute Kidney Injury/diagnosis , Aged , Arrhythmias, Cardiac/diagnosis , Coronary Artery Bypass , Echocardiography , Humans , Infusions, Intravenous , Intraoperative Complications/diagnosis , Male , Potassium/blood , Rhabdomyolysis/diagnosis , SyndromeABSTRACT
This is a case report involving a 71 year old man with generalized tetanus. The patient was initially treated conservatively with sedatives and muscle relaxants, which necessitated intubation and mechanical ventilation. After intrathecal administration of baclofen all cramps and spasms subsided and the patient could be weaned from the respirator and subsequently discharged from the intensive care unit.
