ABSTRACT
A uterine CD8-positive, HTLV-1-negative T-cell lymphoma associated with atypical endometrial hyperplasia was found in a 63-year-old Japanese woman. Primary T-cell lymphoma of the uterus has not been previously reported.
Subject(s)
Lymphoma, T-Cell/diagnosis , Uterine Neoplasms/diagnosis , Blotting, Southern , CD8 Antigens/analysis , Endometrium/pathology , Female , Gene Rearrangement, beta-Chain T-Cell Antigen Receptor , Humans , Hyperplasia , Lymphoma, T-Cell/genetics , Lymphoma, T-Cell/pathology , Middle Aged , Uterine Neoplasms/genetics , Uterine Neoplasms/pathologyABSTRACT
This report describes a case of light chain deposition disease (LCDD) with unusual findings of fibrillar structures in the deposits and marked calcification in several organs. A forty-year-old man was initially diagnosed with LCDD in 1987, and died of sepsis three and one-half-years later. Histological examination of autopsy specimens demonstrated eosinophilic amorphous materials, which differed from amyloid, in vessel walls or around parenchymal cells in almost every organ examined. Ultrastructurally, in addition to granular deposits, fibrillar structures were also seen in the deposits. Marked calcification was present in the myocardium, skeletal muscles, adrenal glands and arteries.
