ABSTRACT
The effects of low doses of deltamethrin administered to female rats on the reproductive system of male offspring were examined. The dams (n=10-12/group) were treated daily by oral gavage with 0, 1.0, 2.0, and 4.0 mg deltamethrin/kg from day 1 of pregnancy to day 21 of lactation. Maternal and reproductive outcome data and male sexual development landmarks were assessed. Fertility, sexual behavior, and a large number of reproductive endpoints, such as organ weights, sperm evaluations, testosterone concentration, and testicular histology were examined on adult male offsprings. No signs of maternal toxicity were detected at the dose levels tested. Significantly adverse effects were only seen on testicular and epididymal absolute weights and the diameter of seminiferous tubules in the group treated with the highest dose of deltamethrin (4.0 mg/kg). The results indicate that in utero and lactational exposure to deltamethrin may induce subtle changes in reproductive behavior and physiology of male offspring rats at dose levels that do not cause maternal toxicity.
Subject(s)
Fertility/drug effects , Insecticides/adverse effects , Prenatal Exposure Delayed Effects , Pyrethrins/adverse effects , Sexual Behavior, Animal/drug effects , Testis/pathology , Animals , Female , Insecticides/administration & dosage , Lactation , Male , Nitriles , Pregnancy , Pyrethrins/administration & dosage , Rats , Rats, Wistar , Testis/anatomy & histologyABSTRACT
Concern over the possibility of hormonal systems being disrupted by chemicals in the environment has led to the development of assays to detect such chemicals. Technical and formulated deltamethrin, a widely used synthetic pyrethroid pesticide, was screened for (anti)estrogenic and (anti)androgenic activities by means of two major in vivo short-term screening tests: the uterotrophic and Hershberger assays. The results reported here indicate the absence of in vivo (anti)estrogenic and (anti)androgenic activities for both technical and formulated deltamethrin at the dose levels tested (2.0 and 4.0 mg/kg/day). However, further tests, including in vitro screening assays, are required to characterize fully the lack of endocrine action of these chemicals.
Subject(s)
Androgen Antagonists/toxicity , Estrogen Receptor Modulators/toxicity , Insecticides/toxicity , Prostate/drug effects , Pyrethrins/toxicity , Seminal Vesicles/drug effects , Uterus/drug effects , Animals , Biological Assay , Dose-Response Relationship, Drug , Estradiol/pharmacology , Female , Male , Nitriles , Orchiectomy , Prostate/pathology , Rats , Rats, Wistar , Seminal Vesicles/pathology , Testosterone/pharmacology , Uterus/pathologyABSTRACT
Utilizou-se 10 cäes, os quais foram submetidos a um preparo de colo por meio de dieta, enemas e antibiótico. Realizou-se uma ressecçäo segmentar do retossigmóide e anastomose colorretal em reto extraperitoneal. Classificou-se o grau de limpeza do colo durante o ato operatório, acompanhou-se a evoluçäo pós-operatória destes animais por duas semanas e realizou-se a contagem de colônias bacterianas aeróbicas e anaeróbicas na mucosa do colo destes animais com e sem preparo de colo. Concluem que método de preparo de colo é satisfatório e obteve-se limpeza adequada em todos os animais apesar de näo haver reduçäo estatísticamente significativa do número de colônias bacterianas
