1.
Bioorg Med Chem Lett
; 17(13): 3736-40, 2007 Jul 01.
Article
in English
| MEDLINE
| ID: mdl-17467986
ABSTRACT
A series of isoxazole derivatives were synthesized and their antagonistic activities against LPA stimulation on both LPA(1)/CHO cells and rHSC cells were evaluated. Among them, 3-(4-[4-[1-(2-chloro-cyclopent-1-enyl)-ethoxycarbonylamino]-isoxazol-3- y]]-benzylsulfanyl)-propionic acid (34) showed the most potent activities.