[A complete response persisting for seven months with the use of TS-1 in a patient with paraaortic lymph node metastasis of gastric cancer].

TS-1, a novel oral anticancer agent, was administered to a 68-year-old male patient with a paraaortic lymph node metastasis, 42 x 28 mm in size, of gastric cancer. The patient received four courses of treatment. Each treatment course consisted of a four-week administration followed by two drug-free weeks. The daily dose was 120 mg for the first two courses and 100 mg for the last two. A partial response was obtained after completion of the first course and a complete response was observed after the second. As of February, 2000, eleven months after the first administration, no regrowth of the tumor was observed either radiographically or by tumor marker levels. Adverse effects included stomatitis (grade 1), neutropenia (grade 3) and anemia (grade 1), all of which were temporary and needed no treatment. The patient's QOL improved gradually after the treatment. He is now in a good health and undergoes regular check-ups.

A molecular orbital treatment on the reactivity of some polycyclic aromatic hydrocarbon diol-epoxides.

The total energies of several aromatic hydrocarbon diol-epoxides and their carbonium cations were calculated by using the semi-empirical CNDO/2 SCF MO calculations. The reactivity of the diol-epoxides toward electrophilic reagents was evaluated from the energy difference between the diol-epoxide and its carbonium cation. Next, the total energies of the diol-epoxides and their carbonium cations were divided into several components, which represent the contributions of parts of molecules to the total energy. That is, the total energy was represented as the sum of the block energies and inter-block energies, which were defined in relation to the parts of the molecules. By using this concept of the block and the inter-block energies the reactivities of the diol-epoxides were interpreted in connection with the molecular structure.