ABSTRACT
The purpose of this study was to educate operators regarding cardiac catheterization using radiation protection slides prepared for this study and to consider whether or not this radiation protection education contributes to reducing the exposure of the operator's ocular lens. Thermoluminescent dosimeter (TLD) was installed at the outside left, inside left, outside right, and inside right of the X-ray protective eyewear of the operators performing the cardiac catheterization. The exposure dose rate before and after radiation protection education for 3 operators performing cardiac catheterization was compared. The exposure dose ratio was defined by dividing the TLD measurement value, which is the air kerma calculated by the X-ray diagnosis apparatus for the angiography. In other words, this can calculate the ratio of how much the operators are exposed to radiation from the dose of the patient per examination. When comparing the radiation dose ratio obtained from the dosimeter installed on the right outer side before and after education, p-value was <0.05 in the left anterior oblique-cranial and right anterior oblique- cranial, and a significant difference was recognized. The radiation protection education carried out in this study contributes to a reduction in the exposure dose of the operators.
Subject(s)
Occupational Exposure , Radiation Exposure , Radiation Protection , Cardiac Catheterization , Humans , Radiation Dosage , Radiation Exposure/prevention & control , Radiography, InterventionalABSTRACT
Autoimmune thyroid diseases (AITDs), including Hashimoto's disease (HD) and Graves' disease (GD), are archetypes of organ-specific autoimmune diseases, but the prognosis of patients with AITD varies. Autoimmune diseases, including AITDs, are believed to develop in response to both genetic and environmental factors. Interleukin (IL)-6 plays a major role in B cell differentiation and T cell proliferation, and methylation of the IL6 gene is associated with IL-6 production. To clarify the role of IL6 gene methylation in the pathogenesis and prognosis of AITDs, we measured the methylation levels of -666, -664, -610, -491 and -426 CpG sites in the IL6 gene. We measured the methylation levels of 5 CpG sites in 29 patients with HD, 31 patients with GD and 16 healthy volunteers using pyrosequencing. The methylation level at each of the -664, -491 and -426 CpG sites was negatively correlated with the age at the time of sampling. Multiple regression analysis indicated that patients with HD, including severe or mild HD, showed higher methylation levels at the -426 CpG site than control subjects. Patients with intractable GD showed lower methylation levels at the -664 and -666 CpG sites than patients with GD in remission. In conclusion, IL6 gene methylation levels were related to the susceptibility to HD and the intractability of GD.
Subject(s)
DNA Methylation , Genetic Predisposition to Disease , Graves Disease/genetics , Hashimoto Disease/genetics , Interleukin-6/genetics , Adult , Aged , Alleles , Antithyroid Agents/therapeutic use , Autoantibodies/blood , Case-Control Studies , CpG Islands , Disease Progression , Female , Gene Expression , Gene Frequency , Graves Disease/diagnosis , Graves Disease/drug therapy , Graves Disease/immunology , Hashimoto Disease/diagnosis , Hashimoto Disease/drug therapy , Hashimoto Disease/immunology , Humans , Interleukin-6/blood , Interleukin-6/immunology , Male , Methimazole/therapeutic use , Middle Aged , Prognosis , Promoter Regions, Genetic , Severity of Illness Index , Thyrotropin/blood , Thyrotropin/immunology , Thyroxine/blood , Thyroxine/immunology , Thyroxine/therapeutic use , Triiodothyronine/blood , Triiodothyronine/immunologyABSTRACT
It is expected that proton beam radiotherapy will become an effective treatment for tumors. For an organ for which a correct dose prescription is required, a proton beam has the ability to provide the dose most suitable for the specific purpose. We measured the charged particle equilibrium factor of proton beams in water using a plane parallel ionization chamber. The maximum energy of the proton beam used in this study was 70 MeV, produced from an isochronous cyclotron. We assume that the charged particle equilibrium factor can be separated into longitudinal and lateral components, that is, the factor E (Z, R) is dependent on depth, Z, and field radius, R; such that E (Z, R) =E (Z) E (R). The E (Z) -factor of primary protons was considered in order to investigate the influence of secondary charged particles. From the results, the charged particle equilibrium factor for the longitudinal component does not remain sharp with the decrease of water depth, and the lateral component is not maintained with the decrease of field size. However, the longitudinal components of primary protons at shallow depth were in equilibrium.
