1.
J Org Chem
; 83(19): 11541-11551, 2018 Oct 05.
Article
in English
| MEDLINE
| ID: mdl-30179462
ABSTRACT
A new approach for the synthesis of highly functionalized tetrahydrocyclohepta[ b]indoles through [5 + 2] cycloaddition was developed. Two carbon-carbon bonds were formed by the simple addition of an indium catalyst, which acted as both a π-Lewis acid and σ-Lewis acid to activate the alkyne and unsaturated ester, respectively. The reaction could be applied to various substrates and proceeded regio- and diastereoselectively in all cases.