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1.
Radiobiologiia ; 31(1): 82-6, 1991.
Article in Russian | MEDLINE | ID: mdl-2008528

ABSTRACT

Dynamics of recovery of humoral immunity of CBA mice was studied 1, 3, 6 and 12 months after termination of long-term exposure to tritium oxide at various levels of absorbed doses (3, 5 and 9 Gy) and dose rates (3.3, 4.9 and 9.2 cGy.day-1). A severer and more stable residual radiation damage was observed in the department of lymphocyte precursors. A considerable decrease in the content of antibody producers was due to the lymphoid tissue hypoplasia. There was a direct relationship between the immunodeficiency and dose rate and total absorbed dose of beta radiation.


Subject(s)
Antibody Formation/radiation effects , Tritium/pharmacology , Water/pharmacology , Animals , Antibody Formation/immunology , Antibody-Producing Cells/immunology , Antibody-Producing Cells/radiation effects , Colony-Forming Units Assay , Dose-Response Relationship, Radiation , Hematopoietic Stem Cells/immunology , Hematopoietic Stem Cells/radiation effects , Immunization , Male , Mice , Mice, Inbred CBA , Spleen/immunology , Spleen/radiation effects , Time Factors
2.
Radiobiologiia ; 30(5): 709-11, 1990.
Article in Russian | MEDLINE | ID: mdl-2251367

ABSTRACT

Wistar rats were subjected to a single exposure to 239Pu nitrate through inhalation with the subsequent procedure of imitation of inhalation or without it (the amount of 239Pu deposited in the lungs in 24 hr was 8.9 +/- 1.9 kBq/lung) and inhalation of hexachlorobutadiene and tributyl phosphate within one month in a combination with the radionuclide or without it. There was a 1.5-fold increase, above additive, in the harmful effect of 239Pu and chemical agents on the function of natural killers as observed 15--30 days after the combined exposure as compared to individual inhalation. On days 120 to 240 cell cytotoxic activity in rats of all groups was normalized to reach or to exceed the intact control.


Subject(s)
Butadienes/administration & dosage , Cytotoxicity, Immunologic , Killer Cells, Natural/immunology , Nitrates , Organophosphates/administration & dosage , Plutonium/administration & dosage , Administration, Inhalation , Animals , Indicators and Reagents/administration & dosage , Killer Cells, Natural/drug effects , Killer Cells, Natural/radiation effects , Male , Rats , Rats, Inbred Strains
3.
Radiobiologiia ; 30(1): 98-102, 1990.
Article in Russian | MEDLINE | ID: mdl-2315466

ABSTRACT

Effective and ineffective levels of the isolated and combined action of inhaled 239Pu and external gamma radiation on dogs were estimated by some changes in the ECG. Specific share of each factor in the combined effect and the quality coefficient of 239Pu were estimated by two criteria of changes in the ECG. The data were extrapolated to man by the most reliable criterion, that is, the decrease in the ECG voltage indicated by the sum of R I, II, III waves.


Subject(s)
Electrocardiography/radiation effects , Plutonium/pharmacology , Administration, Inhalation , Animals , Dogs , Female , Gamma Rays , Heart Rate/radiation effects , Male , Plutonium/administration & dosage , Relative Biological Effectiveness
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