1.
Bioorg Med Chem Lett
; 11(23): 3019-21, 2001 Dec 03.
Article
in English
| MEDLINE
| ID: mdl-11714601
ABSTRACT
Piperidinyl carboxylic acid-based derivatives were prepared as antagonists of the leukocyte cell adhesion process that is mediated through the interaction of the alpha(4)beta(1) integrin (VLA-4, very late antigen 4) and the vascular cell adhesion molecule 1 (VCAM-1). Compounds 2a-h inhibited the adhesion in a cell-based assay in the low and sub micromolar range, a pharmacokinetic study of 2d is reported.