Implementing of Fourier Deconvolution Multiplexing to Fast Polarity Switching Miniaturized Ion Mobility Spectrometer.

Ion mobility spectrometry (IMS) is a reliable and sensitive technique for the detection and analysis of compounds at the trace level. Depending on the chemical composition of the sample, compounds may be positively or negatively charged to form different polarity ions and detected in positive or negative polarity of the electric field. In order to detect multiple threats simultaneously with miniaturized devices, using a single detection unit to achieve high resolving power and high sensitivity is important. In this work, a miniaturized drift tube with fast polarity switching capabilities integrated with Fourier deconvolution multiplexing techniques is proposed for the first time as a means to improve the performance of ion mobility spectrometry. The sensitivity and resolving power are improved compared to traditional polarity switching signal averaging data acquisition methods. The displayed device had a high resolving power up to 52 at a drift length of 41 mm and a drift tube voltage of 2 kV. Trinitrotoluene (TNT), methamphetamine (MA), benzene, toluene, methyl tert-butyl ether (MTBE), acetic acid, and methylene chloride were evaluated using the proposed fast polarity switching multiplexing spectrometer and exhibited satisfied performance.

Simulating, Predicting, and Minimizing False Peaks for Hadamard Transform Ion Mobility Spectrometry.

Multiplexing techniques, including the Hadamard transform, are widely used in the recovery of weak signals from high-level noise. Hadamard transform ion mobility spectrometry (HT-IMS), however, can suffer serious drawbacks due to false peaks. False peaks in HT-IMS are generally attributed to nonperfect gating behavior. This paper confirmed that the origin of false peaks in HT-IMS is not generally due to ion gating but rather to peak shifts by Coulombic repulsion of the ion packets inside the drift tube. The amplitudes of these false peaks are determined by the number of ions inside the ion packets. This phenomenon is simulated and confirmed by the convolution of the spectrum with a shifted s-sequence to reproduce the artifact peaks with the exact position, amplitude, and profile. Two approaches, including preoffset sequence modulation and post-data processing, were evaluated to mitigate the false peaks in HT-IMS, and both methods can work effectively.