ABSTRACT
Clinical use of Amoxiclav showed high therapeutic efficacy in patients with purulent meningoencephalitis both alone and in combination with cefalosporinum of the first generation. Against the background of treatment of patients with overt manifestations of meningoencephalitis and neurotoxicosis meningeal and encephalitic manifestations got attenuated during the first week, with liquorodynamics being stabilized, cerebrospinal fluid ameliorating by day 8-10 of the disease course. Bacteriologic assays showed that up to 83.4% of bacterial flora most common in Ukraine are sensitive to Amoxiclav, with such pathogenic organisms as Pneumococcus, Meningococcus, hemophilia bacillus that are actually main pathogens implicated in acute meningoencephalitis in Ukraine being sensitive to the above drug preparation in 100% of cases.
Subject(s)
Amoxicillin-Potassium Clavulanate Combination/administration & dosage , Drug Therapy, Combination/administration & dosage , Meningoencephalitis/drug therapy , Acute Disease , Adolescent , Adult , Amoxicillin-Potassium Clavulanate Combination/pharmacology , Bacteria/drug effects , Drug Evaluation , Drug Therapy, Combination/pharmacology , Female , Humans , Male , Meningoencephalitis/diagnosis , Meningoencephalitis/microbiology , Microbial Sensitivity Tests , Retrospective StudiesSubject(s)
Anti-Infective Agents/therapeutic use , Communicable Diseases/drug therapy , Ofloxacin/therapeutic use , Acute Disease , Adult , Anti-Infective Agents/pharmacology , Bacteria/drug effects , Communicable Diseases/blood , Female , Humans , Interferons/blood , Interferons/drug effects , Male , Microbial Sensitivity Tests , Middle Aged , Ofloxacin/pharmacology , Time FactorsABSTRACT
High-active interferon was used in the complex treatment of 49 patients with nervous system diseases of viral-bacterial etiology. A control group of 28 similar patients were also analyzed. A positive clinical effect was observed in early use of interferon. The clinical course of the disease was milder, the duration of clinical symptoms reduced, healing of the CSF was enhanced, the development of protracted forms of the disease was preventable, lethality reduced 2.9 times with interferon in the complex treatment of these patients.