[Various aspects of production of a therapeutic form of liposomal cytarabine]. / Nekotorye aspekty sozdaniia lekarstvennoi formy liposomal'nogo preparata tsitarabina.

In the process of preparation of the liposomal cytostatic drug cytarabine for intravenous injection, the influences of the lipid composition of liposomes, the cryoprotector, and the technique of its administration on the liposome intactness were studied by HPLC. It was shown, that under certain conditions the use of definite components allows for preparing a dosage form of lyophylized sterile liposomal cytarabine capable of being stored for a year.

[Effect of lipid emulsifiers on the properties of organoperfluorine emulsions]. / Vliianie lipidnykh émul'gatorov na svoistva émul'sii perftor- organicheskikh soedinenii.

The preparation and application of a new type of organoperfluorine (OPF) emulsions with lipids serving as emulsifiers, their biological and physicochemical properties are discussed. The first-generation emulsions with the nonionic emulsifier, ethylene and propylene oxide blockpolymer, were found to be complementary active and to affect the system's biological properties. Interactions between OPF and phospholipids are analysed. The compositions of the new type OPF emulsions are given, of which perfluoroctyl bromide and perfluoromethyl adamantine emulsions are shown to be currently of most interest, since they are stable at room temperature and exhibit somewhat superior physicochemical and biological parameters. A conclusion is derived that the developed lipid-based OPF emulsions have good clinical prospects.