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J Pediatr (Rio J) ; 92(4): 414-20, 2016.
Article in English | MEDLINE | ID: mdl-27131015

ABSTRACT

OBJECTIVE: The potential role of procalcitonin (PCT) in the diagnosis of catheter-related bloodstream infection (CRBSIs) is still unclear and requires further research. The diagnostic value of serum PCT for the diagnosis of CRBSI in children is evaluated here. METHOD: This study was conducted between October 2013 and November 2014, and included patients with suspected CRBSI from 1 month to 18 years of age who were febrile, with no focus of infection, and had a central venous catheter. Levels of PCT and other serum markers were measured, and their utility as CRBSI markers was assessed. Additionally, the clinical performance of a new, automated, rapid, and quantitative assay for the detection of PCT was tested. RESULTS: Among the 49 patients, 24 were diagnosed with CRBSI. The PCT-Kryptor and PCT-RTA values were significantly higher in proven CRBSI compared to those in unproven CRBSI (p=0.03 and p=0.03, respectively). There were no differences in white blood cell count and C-reactive protein (CRP) levels between proven CRBSI and unproven CRBSI. Among the 24 patients with CRBSI, CRP was significantly higher among those with Gram-negative bacterial infection than in those with Gram-positive bacterial infections. PCT-Kryptor was also significantly higher among patients with Gram-negative bacterial infection than in those with Gram-positive bacterial infections (p=0.01 and p=0.02, respectively). CONCLUSIONS: The authors suggest that PCT could be a helpful rapid diagnostic marker in children with suspected CRBSIs.


Subject(s)
Bacteremia/blood , Bacteremia/diagnosis , Calcitonin/blood , Catheter-Related Infections/blood , Catheter-Related Infections/diagnosis , Adolescent , Biomarkers/blood , C-Reactive Protein/analysis , Child , Child, Preschool , Female , Gram-Negative Bacterial Infections/blood , Gram-Negative Bacterial Infections/diagnosis , Gram-Positive Bacterial Infections/blood , Gram-Positive Bacterial Infections/diagnosis , Humans , Immunoassay , Infant , Infant, Newborn , Leukocyte Count , Male , Reference Values , Reproducibility of Results , Sensitivity and Specificity , Statistics, Nonparametric
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