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Intern Med ; 58(4): 563-568, 2019 Feb 15.
Article in English | MEDLINE | ID: mdl-30333385

ABSTRACT

Large cell neuroendocrine carcinoma (LCNEC) is a highly malignant cancer originally found in lung in 1991. In extremely rare occasions, primary LCNEC is found in the mediastinum; approximately 40 of such cases have been reported. Due to the limited number of reported cases, a standardized treatment protocol has yet to be established. We report a case of a 66-year-old woman with primary mediastinal LCNEC who presented with superior vena cava syndrome. Emergent radiotherapy was performed, followed by systemic chemotherapy with cisplatin and etoposide, which resulted in a dramatic tumor reduction. This is the first report describing the achievement of a complete response after systemic chemotherapy in a patient with primary LCNEC.


Subject(s)
Antineoplastic Agents/therapeutic use , Carcinoma, Large Cell/drug therapy , Carcinoma, Large Cell/radiotherapy , Carcinoma, Neuroendocrine/drug therapy , Carcinoma, Neuroendocrine/radiotherapy , Cisplatin/therapeutic use , Etoposide/therapeutic use , Mediastinum/physiopathology , Aged , Female , Humans , Lung Neoplasms/drug therapy , Lung Neoplasms/pathology , Lung Neoplasms/radiotherapy , Treatment Outcome
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