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Farmakol Toksikol ; 46(3): 61-7, 1983.
Article in Russian | MEDLINE | ID: mdl-6134638

ABSTRACT

Experiments in vitro and in vivo were made to study and compare anticoagulant activity and acute toxicity of a great number of sulfate polysaccharides isolated from red sea algae. Polysaccharides were identified, producing an appreciable anticoagulant effect similar to that of heparin. The heparin-like effect of polysaccharides from red sea algae depends on the structure of the carbohydrate chain and the degree of macromolecule sulfation.


Subject(s)
Anticoagulants/pharmacology , Polysaccharides/pharmacology , Rhodophyta , Animals , Anticoagulants/toxicity , Blood Coagulation/drug effects , Chemical Phenomena , Chemistry , Heparin/pharmacology , Lethal Dose 50 , Male , Mice , Polysaccharides/toxicity , Rabbits , Structure-Activity Relationship
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