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Ukr Biokhim Zh (1999) ; 82(1): 70-6, 2010.
Article in Ukrainian | MEDLINE | ID: mdl-20684230

ABSTRACT

Energy and structural parameters of monochromanes and trimethylphenols derivatives have been chracterized through the employment of semiempirical methods of quantum chemistry. The correlation has been proved between antiradical, hepatoprotective properties of these compounds and energy and structural of their molecules that confirms the presence of relation between structure activity and electron-donor properties of the investigated monochromanes and trimethylphenols.


Subject(s)
Antioxidants/pharmacology , Chromans/pharmacology , Liver/drug effects , Models, Chemical , Phenols/pharmacology , Quantum Theory , Animals , Antioxidants/chemistry , Chemical Phenomena , Chromans/chemistry , Electron Transport , Endoplasmic Reticulum/drug effects , Endoplasmic Reticulum/metabolism , Intracellular Membranes/drug effects , Intracellular Membranes/metabolism , Lipid Peroxidation/drug effects , Liver/metabolism , Phenols/chemistry , Rats , Structure-Activity Relationship
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