ABSTRACT
Confirmation has been obtained that reducing the content of natural free alcohols in lanolin to below 3%, particularly in the absence of detergent residues, reduces the incidence of positive patch test reactions amongst selected lanolin-sensitive skin patients by 99.3%. Only one reaction out of 149 subjects was recorded.
Subject(s)
Dermatitis, Contact/etiology , Lanolin/adverse effects , Alcohols/analysis , Dermatitis, Contact/diagnosis , Detergents/analysis , Humans , Lanolin/analysis , Patch TestsABSTRACT
A case of methylmethacrylate monomer hypersensitivity in a 76-year-old patient with a cemented endoprosthesis is reported. The accuracy of the method for preoperative testing of a patient's sensitivity is discussed.
Subject(s)
Drug Hypersensitivity , Hip Joint/surgery , Joint Prosthesis/adverse effects , Methylmethacrylates/adverse effects , Aged , Arthroplasty , Female , HumansABSTRACT
A total of 330 patients with eczematous lesions were tested with 27 topical substances. Among the 88 patients with leg ulcers, 85 (2%) were allergic to one or more substances present in one out of two cases of allergy to wool alcohol. Among the 242 patients suffering from eczematous dermatitis, the percentage of allergic reactions reached 54.6%. A great number of allergic reactions of cetyl alcohol (11.2%), chloramphenicol (10%) and sodium lauryl sulfate (6.4%) was observed. These allergens are not included in the European standard series adopted by the ICDRG. The findings are discussed and compared with data taken from the literature.
Subject(s)
Dermatitis, Atopic/diagnosis , Adult , Alcohols/adverse effects , Chloramphenicol/adverse effects , Clinical Trials as Topic , Cosmetics , Dermatitis, Atopic/chemically induced , Dermatitis, Atopic/complications , Drug Compounding , Drug Eruptions/complications , Eczema/complications , Evaluation Studies as Topic , Humans , Leg Ulcer/immunology , Methanol/adverse effects , Middle Aged , Ointments , Patch Tests , Sodium Dodecyl Sulfate/adverse effectsABSTRACT
Observations of 3 different great ichthyotic disorders, no longer responding to local keratolytics and to oral vitamin A are reported: a case of erythrokeratoderma variabilis, one of ichthyosiform erythroderma, and one of bullous ichthyosiform hyperkeratosis. After a week of oral treatment by the ethylester retinoid (Ro 10-9359), the hyperkeratotic component of each disease already improved dramatically. A maintenance treatment had to be continued. With equal or superior keratolytic effects, the retinoid has lower toxicity and less important side-effects than retinoic acid itself. The ethylester retinoid is nowadays the choice oral treatment in these great hyperkeratotic disorders.
Subject(s)
Ichthyosis/drug therapy , Skin Diseases, Vesiculobullous/drug therapy , Tretinoin/therapeutic use , Vitamin A/analogs & derivatives , Adolescent , Drug Evaluation , Female , Humans , Ichthyosis/pathology , Skin Diseases, Vesiculobullous/pathologyABSTRACT
The authors report a case of skin allergy to Fitzroya cupressoides (Alerce), and describe the phytochemical classification of that tropical tree. The method of detection of this skin allergy is detailed.
