[Recovery of various parameters of the functional state of the reproductive system in thymectomized rats as affected by thymic membrane factor]. / Vosstanovlenie nekotorykh pokazatelei funktsional'nogo sostoianiia reproduktivnoi sistemy u timéktomirovannykh krys pod vliianiem membrannogo faktora timusa.

Ten-month-old male rats thymectomized in early post-puberty were ascertained to have lower plasma luteinizing and testicular hormones and higher testicular steroid dehydrogenase activity. Following 24 hours of administration of a thymocyte membrane structural agent, pituitary gonadotropic and gonadal androgenic functions became normal. There was no agreement between the hormonal parameters and the levels of nucleic acids in the testes and prostate.

[Activity of cell-detached 5'-nucleotidase in thymocytes of various densities]. / Aktivnost' otdeliaemoi ot kletok 5'-nukleotidazy v timotsitakh razlichnoi plotnosti.

The rat thymocytes submitted to heating at 45 degrees C for 1 hr liberate plasma membrane fragments containing 5'-nucleotidase activity in the supernatant. The thymocytes were separated by ficoll density gradient centrifugation. High activity of 5'-nucleotidase per 10(6) cells was found in the supernatant of low density (1.069) subset of thymocytes. Thymocyte supernatant of rats treated with hydrocortisone demonstrated higher 5'-nucleotidase activity per 10(6) cells than in intact animals. This is due to an increase of the low density population of thymocytes in treated rats since the 5'-nucleotidase activity per 10(6) cells of the supernatant obtained from this density fraction is the same both in treated with hydrocortisone and intact rats. Hydrocortisone seems to induce a selection of the thymocytes with high 5'-nucleotidase activity.

[Relationship between accumulation of o,p'-dichlorodiphenyl-dichloroethane in the adrenal glands and their function and structure]. / Zavisimost' mezhdu nakopleniem o,p'-dikhlordifenil-dikhloretana v nadpochechnikakh, ikh funktsiei i strukturoi

Over a periof of 12 days following introduction of o'p-dichlordiphenyl-chlorethane to dogs in a dose of 25 mg/kg a sizable accumulation of the compound in the adrenal tissue, a drastic inhibition of its function and deragment of the suprarenal cortex structure are observed. After a 28-day administration of the compound the functional and structural upsets in the adrenals gain in strength, whereas it concentration in this organ declines.