ABSTRACT
In sagittal cerebellum sections, morphometrical study of cerebellum of mature-born animals - guinea pigs - was performed using Nissl's procedure. A change of shape and volume of Purkinje cells and their nuclei in the course of the guinea pig postnatal ontogenesis was studied. It has been shown that both the growth process itself and the rate of formation of the definite form of Purkinje cells and of their nuclei in the course of ontogenesis proceeds non-uniformly. The most intensive growth of vertical and horizontal diameters of Purkinje cells and of their nuclei is observed during the 1st and 4th weeks of postnatal life. Especially rapid is an increase of horizontal diameters of Purkinje cells and of their nuclei, which impairs the ovoid-bear-like shape to the cerebellar Purkinje cells of adult guinea pigs.
Subject(s)
Aging/physiology , Cell Nucleus Shape/physiology , Cell Nucleus Size/physiology , Cell Shape/physiology , Purkinje Cells/physiology , Animals , Guinea Pigs , Purkinje Cells/cytologySubject(s)
Aging/physiology , Evoked Potentials/physiology , Exploratory Behavior/physiology , Motor Activity/physiology , Purkinje Cells/physiology , Animals , Animals, Newborn , Cats , Cell Size , Cerebellum/cytology , Cerebellum/physiology , Guinea Pigs , Microelectrodes , Phylogeny , Physical Stimulation , Purkinje Cells/cytology , RatsABSTRACT
The effect of peptide bioregulator Epithalon on the course of hereditary pigmentary retinal degeneration was studied in Campbell rats. Administration of epithalon starting from birth protected morphological structure, increased its bioelectrical activity, and improved its function.