1.
Enferm Infecc Microbiol Clin
; 21(5): 273-4, 2003 May.
Article
in Spanish
| MEDLINE
| ID: mdl-12732119
2.
Dig Dis Sci
; 48(2): 354-7, 2003 Feb.
Article
in English
| MEDLINE
| ID: mdl-12643615
ABSTRACT
Two patients developed acute cholestatic hepatitis during treatment with propafenone. Viral infections, alcohol abuse, hepatotoxicity by other drugs, and biliary obstruction were excluded as causes. In one patient, liver biopsy showed changes consistent with a drug-associated injury. Another patient had autoimmune antibodies (ANA) in the serum. Following propafenone withdrawal, the clinical and biochemical profiles of both patients improved. Hepatic toxicity from the antiarrhythmic drug propafenone is highly uncommon. Moreover, the drug produces hepatocellular injury by an unknown mechanism. Most of the seven cases reported here had acute cholestatic hepatitis after a latency period of two to four weeks.
Subject(s)
Atrial Fibrillation/drug therapy , Chemical and Drug Induced Liver Injury/etiology , Chemical and Drug Induced Liver Injury/pathology , Propafenone/adverse effects , Aged , Atrial Fibrillation/diagnosis , Biopsy, Needle , Dose-Response Relationship, Drug , Drug Administration Schedule , Female , Follow-Up Studies , Humans , Immunohistochemistry , Liver Function Tests , Propafenone/therapeutic use , Risk Assessment , Severity of Illness Index
3.
Quirón
; 20(1): 10-61, 1989. ilus
Article
in Spanish
| LILACS
| ID: lil-103247
Subject(s)
Adolescent , Adult , Middle Aged , Humans , Male , Female , Thymus Neoplasms/therapy , Thymus Neoplasms/diagnosis , Thymus Neoplasms/pathology
4.
Quirón
; 20(1): 10-61, 1989. ilus
Article
in Spanish
| BINACIS
| ID: bin-26751
