ABSTRACT
The late follow-up results of combined and complex treatment of 305 patients, suffering cancer recti, were analyzed. After the operation in 250 (82%) patients the anticoagulants were administered, including the low-molecular-weight heparin (calcium nadroparine)--129 (42.3%), and nonfractionized heparin--in 121 (39.7%). In 55 (18%) patients the complex and combined treatment was conducted, according to the present standards, without application of anticoagulants. There was proved, that administration of calcium nadroparine in combined and complex treatment of patients, suffering cancer recti, had promoted the patients three-year and five-year survival indices increase due to reduction of the tumors generalization.
Subject(s)
Anticoagulants/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Heparin, Low-Molecular-Weight/therapeutic use , Rectal Neoplasms/drug therapy , Adult , Aged , Aged, 80 and over , Anticoagulants/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Combined Modality Therapy , Disease-Free Survival , Female , Heparin, Low-Molecular-Weight/administration & dosage , Humans , Male , Middle Aged , Rectal Neoplasms/mortality , Rectal Neoplasms/pathology , Rectal Neoplasms/surgeryABSTRACT
The direct dependence between p53 expression in epithelial cells and the level of morphological malignant neoplasm was established as the result of investigation of expression of this biomolecular marker in 12 polyps and 35 colorectal cancer. It was shown that family cancer syndrome 1 type was observed in pedigrees of majority patients with p53 positive cancers.
Subject(s)
Colonic Polyps/genetics , Colorectal Neoplasms/genetics , Gene Expression Regulation, Neoplastic/physiology , Intestinal Mucosa/metabolism , Intestine, Large/metabolism , Tumor Suppressor Protein p53/metabolism , Adult , Aged , Colonic Polyps/metabolism , Colonic Polyps/pathology , Colorectal Neoplasms/metabolism , Colorectal Neoplasms/pathology , Epithelium/metabolism , Epithelium/pathology , Female , Humans , Immunohistochemistry , Intestinal Mucosa/pathology , Intestine, Large/pathology , Male , Middle Aged , PedigreeABSTRACT
A clinical and genealogical investigation has been carried out in 169 subjects of both sexes, presenting with colorectal oncopathology. Particular features of the colorectal carcinoma in the patients have been recognized. The frequency of the tumours spread in the relatives of the probands is determined as is the spectrum of aggregation of large intestine carcinoma with neoplasia of other genesis in the pedigrees. The data obtained suggest an important contribution of genetic factors into the origination of colorectal carcinoma.
