[The determination of chromosome fragile sites in the peripheral blood lymphocytes of patients with colorectal cancer taking into account the cancer pathology predisposition in the familial anamnesis]. / Opredelenie khromosomnoi sait-lomkosti v limfotsitakh perifericheskoi krovi bol'nykh kolorektal'nym rakom s uchetom otiagoshchennosti semeinogo anamneza po onkopatologii.

Results of comparative study of spontaneous and 5-bromdeoxyuridine-induced fragility of peripheral blood lymphocytes chromosomes in 9 patients with colorectal adenocarcinoma were presented. It was shown the increase of average spontaneous level of chromosomal fragility in patients with tumor aggregation in family as well as without it to 4.5 +/- 1.0 and 5.3 +/- 1.1 per 100 tested cells, accordingly. The increase of average level of damaged chromosomes in spectrum of rare sites to 12.5 +/- 2.6 in the patients with tumor aggregation in pedigree comparing to the patients without oncopathology in family 8.0 +/- 1.7 was observed. The most number of rare fragile sites was observed in 1q21 site of the chromosome 1. Possible connection between fragile sites of chromosomes in normal cells and malignant processes in the patients with colorectal cancer is discussed.

[Contemporary information system of collection, processing and system of data on patient with mammary gland cancer]. / Sovremennaia informatsionnaia sistema sbora, obrabotki i analiza dannykh o bol'nykh rakom molochnoi zhelezy.

The experience of elaboration of informational-analytical system for the data collection, processing and analysis about the patients with mammary gland cancer is presented.

[The clinico-genetic characteristics of the origin and manifestation of colorectal cancer]. / Kliniko-henetychni osoblyvosti vynnyknennia ta manifestatsiï kolorektal'noho raku.

A clinical and genealogical investigation has been carried out in 169 subjects of both sexes, presenting with colorectal oncopathology. Particular features of the colorectal carcinoma in the patients have been recognized. The frequency of the tumours spread in the relatives of the probands is determined as is the spectrum of aggregation of large intestine carcinoma with neoplasia of other genesis in the pedigrees. The data obtained suggest an important contribution of genetic factors into the origination of colorectal carcinoma.