Effectiveness of an Ecological Model-Based Active Transport Education Program on Physical and Mental Health in High School Students (MOV-ES Project): Study Protocol for a Randomized Controlled Trial.

The United Nations, through its 2030 Agenda and Sustainable Development Goals, advocates for the establishment of conducive environments for physical activity, following the ecological model. In line with this initiative, active transportation emerges as an accessible, cost-effective, and sustainable approach to augmenting daily physical activity levels. This study protocol endeavors to assess the impact of an active transportation education program rooted in the ecological model on the physical and mental well-being of high school students. Drawing upon scientific insights, we hypothesize that a 16-week active transportation intervention will lead to a 3% reduction in average body fat percentage and a noteworthy enhancement in executive function (including inhibition, cognitive flexibility, and working memory), physical fitness (comprising cardiorespiratory fitness and muscle strength), and mental health (encompassing mood disorders and cognitive functioning). If this intervention proves effective, it could offer a viable solution for the school community, especially in reducing congestion within the school environment. The study protocol aims to evaluate the impact of an active transportation educational program based on the ecological model on the physical and mental well-being of high school students. Three high schools located in the urban area of Talca, Chile, will be randomly selected (one public, one privately subsidized, and one private non-subsidized). Each high school will be randomly assigned an experimental group (n = 30) and a control group (n = 30; without intervention). The experimental groups will receive an active transportation educational intervention during their physical education classes for four months (60 to 90 min sessions, once a week), while the control group will receive no intervention. The primary outcome will provide information on body composition and executive function. Secondary outcomes will include objective physical activity level, physical fitness, mental well-being, academic achievement, health-related quality of life, perception of environmental urban features, physical activity barriers, and adherence to active transportation. It is expected that the results of the MOV-ES Project will transcend the physical health of schoolchildren and will have an impact on the school community, especially by decongesting the school environment.

Intermittent Hypoxic Training Increases and Prolongs Exercise Benefits in Adult Untrained Women.

Alba Camacho-Cardenosa, Marta Camacho-Cardenosa, Johannes Burtscher, Pedro R. Olivares, Guillermo Olcina, and Javier Brazo-Sayavera. Intermittent hypoxic training increases and prolongs exercise benefits in adult untrained women. High Alt Med Biol. 00:00-00, 2024. Background: Exercising in hypoxia may confer multiple health benefits, but the evidence for specific benefits is scarce. Methods: We investigated effects of intermittent hypoxic training (IHT) on the quality of life and functional fitness of healthy adult women, in a double-blind, randomized, placebo-controlled study. Subjects performed 36 sessions of IHT (experimental group, n = 41; fraction of inspired oxygen [FIO2]: 0.17) or the same training in normoxia (control group, n = 41; FIO2: 0.21). Health-related quality of life, fitness tests, and hemoglobin levels were assessed before (T1), directly after (T2), and 4 weeks after (T3) cessation. Results: At T2, upper body strength (+14.96%), lower body strength (+26.20%), and agility (-4.94%) increased significantly in the experimental group compared to baseline but not in controls. The experimental group improved lower body strength more (by 9.85%) than controls at T2 and performed significantly better in walking (by 2.92%) and upper body strength testing (by 16.03%), and agility (by 4.54%) at T3. Perceived general health and vitality was significantly greater in the experimental group at T2 and T3 compared with T1. None of these improvements were observed in the control group. Conclusions: IHT is a promising strategy to induce long-lasting fitness benefits in healthy adult women.

Analysis of the use of public open spaces and physical activity levels in children and adolescents from Rivera (Uruguay).

This study aimed to analyze the use of public open spaces and physical activity levels among children and adolescents in the city of Rivera, Uruguay. A total of 88 target areas located in 29 public open spaces were observed using the System for Observing Play and Recreation in Communities (SOPARC). Systematic observations were made at different times of the day, covering both weekdays and weekends, for a total of 792 records in each public open spaces. Characteristics of the users were recorded according to gender (male and female), age group (infancy to early childhood 0-5 years, middle childhood 6-12 years, adolescence 13-18 years) and physical activity level (sedentary, moderate, or vigorous activity). Logistic regression was employed, considering variables such as day, period, type, and conditions, to assess factors associated with user presence and activity, with separate analyses by gender. Most of the users were adolescents (59.8%) between 13 and 18 years, 67.2% were male and half of the users were sedentary (50.1%). Furthermore, the majority of participants used the target areas on weekends (96.2%), particularly in the evening (99.2%). Multivariate analyses revealed elevated odds of having active girls and boys in the target area during the afternoon and evening, particularly in organized and equipped areas, compared to the morning. Based on this information, it is worth proposing the need to promote the active use of public open spaces in the city of Rivera (Uruguay).

Multicomponent synthesis and photophysical study of novel α,ß-unsaturated carbonyl depsipeptides and peptoids.

Multicomponent reactions were performed to develop novel α,ß-unsaturated carbonyl depsipeptides and peptoids incorporating various chromophores such as cinnamic, coumarin, and quinolines. Thus, through the Passerini and Ugi multicomponent reactions (P-3CR and U-4CR), we obtained thirteen depsipeptides and peptoids in moderate to high yield following the established protocol and fundamentally varying the electron-rich carboxylic acid as reactants. UV/Vis spectroscopy was utilized to study the photophysical properties of the newly synthesized compounds. Differences between the carbonyl-substituted chromophores cause differences in electron delocalization that can be captured in the spectra. The near UV regions of all the compounds exhibited strong absorption bands. Compounds P2, P5, U2, U5, and U7 displayed absorption bands in the range of 250-350 nm, absorbing radiation in this broad region of the electromagnetic spectrum. A photostability study for U5 showed that its molecular structure does not change after exposure to UV radiation. Fluorescence analysis showed an incipient emission of U5, while U6 showed blue fluorescence under UV radiation. The photophysical properties and electronic structure were also determined by TD-DFT theoretical study.

Bullying and Self-Concept, Factors Affecting the Mental Health of School Adolescents.

Bullying is an aggressive and repetitive behavior, where one person or several people physically, socially, or emotionally harm a vulnerable person and provokean imbalance of power in a school setting. Several factors such as age, sex, school performance, psychological factors, and ethnicity have been associated with bullying and more are being sought. Thus, the objectives of this study were as follows: (1) analyze the differences in bullying (victimization and aggression) and self-concept (academic, social, emotional, family, and physical) with respect to sex, school location, and educational level among Spanish adolescents; (2) explore the associations of bullying and self-concept with these sociodemographic dimensions. A cross-sectional study was designed with a total of 1155 participants (between 12 and 18 years old); there were 48.8% boys and 51.2% girls, where 75.9% studied compulsory secondary education (CSE) and 24.1% Baccalaureate, and 31.9% were students from rural schools and 68.1% were from urban schools. Medium and inverse correlations were shown between victimization and self-concept at the general level, for both sexes, both types of school, and both educational stages. For the aggression dimension, the correlations with self-concept were inverse at the general level (low), in girls (low), in rural students (medium), and in compulsory secondary education students (medium). For academic self-concept and family self-concept, the associations were medium and inverse with bullying in all variables. For emotional self-concept the correlation with bullying was direct and medium in all variables; in physical self-concept, the correlations with bullying were inverse in almost all variables except in boys. Self-concept may be a protective factor for bullying and interventions should aim at adolescents building a positive multidimensional self-concept that prevents and protects them from bullying either as aggressor or victim.

Normative Values and Psychometric Properties of EQ-5D-Y-3L in Chilean Youth Population among Different Weight Statuses.

BACKGROUND: This study aimed to provide population norms among children and adolescents in Chile using the EQ-5D-Y-3L questionnaire and to examine its feasibility and validity among body weight statuses. METHODS: This was a cross-sectional study in which 2204 children and adolescents (aged 8-18 years) from Chile completed a set of questionnaires providing sociodemographic, anthropometric and health-related quality of life (HRQoL) data using the five EQ-5D-Y-3L dimensions and its visual analogue scale (EQ-VAS). Descriptive statistics of the five dimensions and the EQ-VAS were categorized into body weight status groups for the EQ-5D-Y-3L population norms. The ceiling effect, feasibility and discriminant/convergent validity of the EQ-5D-Y-3L were tested. RESULTS: The dimensions of the EQ-5D-Y-3L questionnaire presented more ceiling effects than the EQ-VAS. The validity showed that the EQ-VAS could discriminate among body weight statuses. However, the EQ-5D-Y-3L index (EQ-Index) demonstrated a non-acceptable discriminant validity. Furthermore, both the EQ-Index and the EQ-VAS presented an acceptable concurrent validity among weight statuses. CONCLUSIONS: The normative values of the EQ-5D-Y-3L indicated its potential use as a reference for future studies. However, the validity of the EQ-5D-Y-3L for comparing the HRQoL among weight statuses could be insufficient.

Fibromyalgia, Pain, and Physical Activity: A Bibliometric Analysis.

Fibromyalgia (FM) is a rheumatic disease characterized by pain, fatigue, low-quality sleep, depression, anxiety, stiffness, fall risk, mood disturbance, cognitive impairment, poor physical condition, and other symptoms leading to a worse quality of life. Physical activity (PA) and exercise are effective methods to reduce FM symptoms, including pain. This study presents the first bibliometric study on FM, pain, and PA. An advanced search of the Web of Science (WoS) Core Collection database performed on this topic using was carried out traditional bibliometric laws. A total of 737 documents were found. Annual publications presented an exponentially growing trend (R2 = 85.3%). Rheumatology International, Kaisa Mannerkorpi, and the USA were the journal, co-author, and country most productive, respectively. The exponential growth of annual publications on FM, PA, and pain shows the high interest of researchers and publishers in this topic. The document "Fibromyalgia A Clinical Review" was the most cited. Moreover, Kaisa Mannerkorpi was the most prolific co-author, Rheumatology International was the most prolific journal, "Fibromyalgia: a clinical review" was the most highly cited document, and Daniel Clauw was the most cited co-author.

Relationships between Physical Activity Level and Pain in the Spanish Population: A Cross-Sectional Study.

Introduction. One third of the world's population suffers from some form of pain. Physical inactivity is one of the causes that reduces physical fitness and may lead to an increase in the prevalence of pain in the population. Aims. To analyse the relationships between the level of physical activity (PAL) and the prevalence and degree of pain, the limitations and impact of pain on daily activities and the use of pain medication in the Spanish population. Hypothesis. PAL is related to pain among Spaniards. Methodology. A cross-sectional study design was used, based on data obtained from the Spanish National Health Survey 2017 with 17,777 participants. A descriptive analysis was performed. Nonparametric statistical tests were used: chi-square statistic to analyse intergroup differences in ordinal variables; Mann−Whitney U test to analyse intergroup differences in continuous variables. A correlation study was also performed between the variables of interest, using Spearman's rho. Results. Relationships were found between PAL and: prevalence of pain, degree of pain, limitations due to pain in usual activities, level of impact in daily activities and use of pain medication in the Spanish population (p < 0.001). Performing moderate and intense PA was related to lower prevalence and degree of pain in the population that performed it, compared to those who only walked or were inactive. Weak correlations were found between the level of PA and the study variables (p < 0.001). Conclusions. High PALs in the population are related to better indicators of pain among Spaniards, appearing to reduce the prevalence and degree of pain, as well as the limitations and impact caused by pain in the daily activities of citizens, and could reduce the use of pain medication in the adult Spanish population.

Psychometric Properties of the Spanish Versions of EQ-5D-Y-3L and EQ-5D-Y-5L in Children with Cancer: A Comparative Study.

(1) Background: The recent published version with five levels of response of EQ-5D-Y needs to be studied in children with chronic illness. For this, the aim of the present study was to assess and compare the psychometric properties of EQ-5D-Y-3L and EQ-5D-Y-5L in terms of feasibility, ceiling effect, redistribution properties, informativity and inconsistence responses in children with cancer. (2) Methods: A core set of self-report tools, including the Spanish version of EQ-5D-Y-3L and EQ-5D-Y-5L, were administered to children drawn from the population with cancer. EQ-5D-Y-3L and EQ-5D-Y-5L were evaluated in terms of feasibility, ceiling effects, redistribution properties and differences in absolute and relative informativity. (3) Results: A total of 73 children (9.7 ± 2.3 years old) from the population with cancer participated in the study. No missing data in the new EQ-5D-Y-5L were visualized, so the feasibility was acceptable. EQ-5D-Y-5L showed a low ceiling effect in all dimensions with relative changes from EQ-5D-Y-3L to EQ-5D-Y-5L of between 15.3% and 42.4% for the dimensions and 44.6% for the overall system. Compared to EQ-5D-Y-3L, EQ-5D-Y-5L provided a better distribution of the severity of the problem in the five levels of response. The absolute informativity (Shannon's index) did not show statistically significant differences between EQ-5D-Y-3L and EQ-5D-Y-5L in all dimensions and the overall system. (4) Conclusions: EQ-5D-Y-5L is feasible, presenting a low ceiling effect and high discriminative power.

Influencia de los factores socioeconómicos en la ocurrencia de quemaduras en edades pediátricas / Influence of socioeconomic factors on the occurrence of burns in pediatric ages

Introducción: Los accidentes no se presentan solos, casi siempre están relacionados con un factor social y con el entorno cultural. Se plantea que las condiciones socioeconómicas impactan en la salud de las personas. Objetivos: Determinar los factores socioeconómicos que influyen en la ocurrencia de quemaduras en edades pediátricas. Métodos: Estudio descriptivo transversal realizado en la sala de Caumatología del Hospital Dr. Juan Bruno Zayas Alfonso de Santiago de Cuba, en el 2017. Se utilizó el Sistema SPSS. Se determinaron la frecuencia absoluta y el porcentaje. Resultados: El grupo de edad más afectado fueron los niños de 1-4 años. No se encontró diferencias con relación al sexo. Los líquidos hirvientes fueron el agente causal que predominó. Sobresalieron las familias con 1 o 2 hijos y de bajos ingresos. En la casuística estudiada el 71,7 por ciento de los familiares tenía escasos conocimientos sobre la prevención y primeros auxilios de las quemaduras El 41,7 por ciento de las familias tenían algún familiar que fumaba. Conclusiones: La interacción de factores sociales con factores económicos influye en la ocurrencia de quemaduras y otras afecciones en edades pediátricas, siendo los más vulnerables el grupo de 1-4 años de edad(AU)

Introduction: Accidents do not occur isolated, they are almost always related to a social factor and the cultural environment. It is proposed that socioeconomic conditions impact on people's health. Objectives: To determine the socioeconomic factors that influence the occurrence of burns in pediatric ages. Methods: Cross-sectional descriptive study conducted in the Caumatology room of Dr. Juan Bruno Zayas Alfonso Hospital, Santiago de Cuba province, in 2017. The SPSS System was used. Absolute frequency and percentage were determined. Results: The most affected age group were children aged 1-4 years. No differences were found in relation to sex. Boiling liquids were the predominant causative agent. Families with 1 or 2 children and low incomes stood out. In the case studies, 71.7 percent of the relatives had little knowledge about the prevention and first aid of burns. 41.7 percent of the families had a family member who smoked. Conclusions: The interaction of social factors with economic factors influences the occurrence of burns and other conditions in pediatric ages, being the most vulnerable the group of 1-4 years old(AU)

Science Mapping: A Bibliometric Analysis on Cyberbullying and the Psychological Dimensions of the Self.

Cyberbullying prevalence is increasing in the world, being a form of abuse that follows victims into their most intimate settings. Cyberbullying affects victims' mental health, self-esteem, emotions, and academic performance. Cyberbullies present low levels of self-control and empathy. This research aimed to map scientific research on Cyberbullying and the Psychological Dimensions of the Self. A bibliometric analysis of scientific documents published in journals indexed in the Web of Science (WoS) was performed. Traditional bibliometric laws were applied and VOSviewer was used to generate visualizations. The annual publications followed exponential growth. Computers in Human Behaviour was the journal with the most publications. Researchers from the USA and Spain were the most prolific. Sameer Hinduja and Justin Patchin were the most cited authors. Hence, there is a growing interest among researchers in Cyberbullying and the emotional aspects of children and adolescents. The USA and Spain were the leading countries in research on this subject. Rosario Ortega-Ruiz, Sameer Hinduja and Justin Patchin were the most prolific and influential authors.

Comparison of the Psychometric Properties of the EQ-5D-3L-Y and EQ-5D-5L-Y Instruments in Spanish Children and Adolescents.

OBJECTIVES: The study aimed to assess the reliability and validity of EQ-5D-5L-Y and to compare the performance of EQ-5D-5L-Y with EQ-5D-3L-Y in children and adolescents. METHODS: The Spanish versions of the 3L and 5L of EQ-5D for youths, were administered to children and adolescents from the general population. Feasibility and reliability were determined for the EQ-5D-5L-Y. The EQ-5D-5L-Y and EQ-5D-3L-Y were evaluated in terms of ceiling effects, informativity, and correlations with other generic measurements of health-related quality of life. RESULTS: A total of 714 healthy children and adolescents (10.7 ± 2.1 years old) from the general population participated in the study. Most of the sample reported full health status. The feasibility and reliability for the EQ-5D-5L-Y were acceptable, but the questionnaire showed a low convergent validity. Absolute informativity (Shannon index) showed a slight increase in all dimensions of the 5L compared with the 3L; nevertheless, there were only statistically significant differences between 5L and 3L in the dimension "feeling worried, sad, or unhappy" and also on the overall system. Relative informativity (Shannon evenness index) showed a decrease in the 5L compared with 3L for all dimensions, except for "looking after myself." Correlations with other health measurements, in both 3L and 5L, showed similar results to those observed in the international EQ-5D-3L-Y validation study. CONCLUSION: The results show that EQ-5D-5L-Y is feasible, consistent, and reliable, but there are minor differences in the ceiling effect and informativity between the EQ-5D-5L-Y and EQ-5D-3L-Y versions in the general population.

Estimation of Pubertal Growth Spurt Parameters in Children and Adolescents Living at Moderate Altitude in Colombia.

Objective: Knowledge of the biological parameters of pubertal growth spurt allows verification of secular changes and exploration of the timing of puberty. The aim of the study was to estimate final height, age at peak height velocity (APHV), and peak height velocity PHV (cm/y) in children and adolescents living at moderate altitude in Colombia. Methods: A cross-sectional study was designed in 2.295 schoolchildren from Bogotá (Colombia) with an age range from 5.0 to 18.9 years. Height (cm) was assessed. Preece-Baines model 1 (1PB) was used to make inferences about mathematical and biological parameters. Results: The five mathematical parameters estimated in general have reflected quality in the fit to the model, reflecting a small residual error. Final height was reached in boys at 170.8 ± 0.4 cm and in girls at 157.9 ± 0.2 cm. APHV was estimated at 12.71 ± 0.1 years in boys and 10.4 ± 0.2 years in girls. Girls reached APHV 2.2 years earlier than boys. In relation to PHV (cm/y), boys reached higher growth speed in height (7.4 ± 0.4 cm/y), and in girls it was (7.0 ± 0.2 cm/y). Conclusion: It was determined that final height was reached at 170.8 ± 0.4 cm in boys and 157.9 ± 0.2 cm in girls, and APHV (years) and PHV (cm/ye) were reached relatively early and with average peak velocity similar to Asian and Western populations. A large-scale longitudinal study is needed to confirm these findings.

The Effect of Social Isolation on Physical Activity during the COVID-19 Pandemic in France.

The objective of this cross-sectional study is to analyze the changes in physical activity (PA) practice of a sample of 2099 French adults, mostly females, who answered an online questionnaire during the first COVID-19 lockdown (March-May 2020). A descriptive analysis of participants was performed using relative frequencies. Chi-squared tests were performed to compare the responses of selected variables. Multinomial logistic regressions were performed to compare the variations of PA with all the variables identified. The age of participants ranged from 18 to 88. Among people who practiced PAs before the first lockdown, the probability to keep practicing PAs is higher among those with a lower level of education, among housewives and retirees and among those who lived in cities of 10,000-19,999 inhabitants. For those who did not practice PAs before the social distancing, the probability of starting to practice is greater in those with a lower level of education and for those who suffered from a chronic disease. Our results place the emphasis on the complexity and multifactoriality of the changes that emerged during the first lockdown. The "education" factor emerges, as a significant determinant of PA that should certainly be explored further.

Determinantes sociales y de salud en niños y adolescentes con quemaduras / Social and health determinants in children and adolescents with burns

Introducción: En Cuba, las quemaduras se han mantenido entre las 5 primeras causas de muerte por accidentes y en la población infantil constituyen un problema de salud. Objetivo: Describir algunos determinantes sociales de salud en niños y adolescentes con quemaduras. Método: Se realizó un estudio descriptivo y transversal de 60 pacientes, hasta los 18 años edad, atendidos en el Servicio de Caumatología del Hospital General Docente Dr. Juan Bruno Zayas Alfonso de Santiago de Cuba durante 2017. Para el procesamiento de la información se empleó el paquete estadístico SPSS, versión 11.5 para Windows, así como la frecuencia absoluta y el porcentaje para el análisis de los resultados. Resultados: En la serie predominaron los pacientes de 1-4 años de edad (41,6 %), los líquidos hirvientes como principal agente causal de las quemaduras (45,0 %), además de los problemas relacionados con el abasto de agua, con el sistema de depósito de residuales, el piso de tierra en las viviendas (18,3 %), el uso de la energía de alto riesgo para cocinar (53,9 %) y el hacinamiento (46,6 %). Conclusiones: Mediante la identificación de los determinantes sociales en la comunidad se pueden detectar posibles modos de enfermarse y trazar estrategias con vistas a prevenir enfermedades y lograr poblaciones sanas.

Introduction: In Cuba, burns have stayed among the first 5 causes of death due to accidents and constitute a health problem in the youth population. Objective: To describe some social health determinant in children and adolescents with burns. Method: A descriptive and cross-sectional study of 60 patients, up to 18 years was carried out. They were assisted in the Caumatology Service of Dr. Juan Bruno Zayas Alfonso Teaching General Hospital in Santiago de Cuba during 2017. The SPSS statistical package, version 11.5 for Windows, was used to process the information, as well as the absolute frequency and the percentage for the analysis of the results. Results: In the series there was a prevalence of the 1-4 age group (41.6 %), boiling liquids as main causal agent of burns (45.0 %), besides the problems related to water supply, residual deposit system, houses with no tiled floor (18.3 %), use of high risk energy to cook (53.9 %) and overcrowding (46.6 %). Conclusions: By means of the identification of social determinants in the community possible ways of getting sick can be detected and draw up strategies aimed at preventing diseases and achieve healthy populations.

Role for Physical Fitness in the Association between Age and Cognitive Function in Older Adults: A Mediation Analysis of the SABE Colombia Study.

Objectives. We investigated the association between physical fitness and cognitive status. Further, we examined whether physical fitness mediates the association between cognitive functioning and aging. Design. Cross-sectional study. Setting. Urban and rural Colombian older adults. Methods. 4416 participants from the SABE study were included in the current analysis. Physical fitness was assessed with the handgrip test and the usual gait speed test. Cognitive status was evaluated through the Folstein Mini-Mental State Examination. A parallel mediation path was used to test the possible mediator role of physical fitness between aging and cognitive functioning. Results. Older adults with lower handgrip strength (HGS) were more likely to have mild-cognitive status than older adults with healthy HGS (OR = 1.53, 95% CI = 1.15; 2.02). In addition, older adults with a slower gait speed were more likely to have mild cognitive impairment (OR = 2.05, 95% CI = 1.54; 2.78). Age had an inverse relationship with cognitive function (ß = -0.110, 95% CI = -0.130; -0.100) and it was also inversely associated with HGS (ß = -0.003, 95% CI = -0.005; -0.002) and gait speed (ß = -0.010, 95% CI = -0.011; -0.009). The indirect effects, which indicate that the effect of age on cognitive function is transmitted through mediators, showed that both gait speed (ß = -0.028, 95% CI = -0.036; -0.020) and HGS (ß = -0.014, 95% CI = -0.024; -0.005) were independent mediators of the detrimental effect of aging on cognitive function. Conclusions. Physical fitness mediates the effects of aging on cognitive functioning. Our findings suggest that physical activity can be a key factor to prevent cognitive deterioration during aging process.

Green by Design: Convergent Synthesis, Computational Analyses, and Activity Evaluation of New FXa Inhibitors Bearing Peptide Triazole Linking Units.

Green chemistry implementation has led to promising results in waste reduction in the pharmaceutical industry. However, the early sustainable development of pharmaceutically active compounds and ingredients remains a considerable challenge. Herein, we wish to report a green synthesis of new pharmaceutically active peptide triazoles as potent factor Xa inhibitors, an important drug target associated with the treatment of diverse cardiovascular diseases. The new inhibitors were synthesized in three steps, featuring cycloaddition reactions (high atom economy), microwave-assisted organic synthesis (energy efficiency), and copper nanoparticle catalysis, thus featuring Earth-abundant metals. The molecules obtained showed FXa inhibition, with IC50-values as low as 17.2 µM and no associated cytotoxicity in HEK293 and HeLa cells. These results showcase the environmental potential and chemical implications of the applied methodologies for the development of new molecules with pharmacological potential.

Asociación entre relaciones peso-estatura y grasa subcutánea en jóvenes universitarios peruanos / Association between weight-height ratios and subcutaneous fat in young Peruvian university students

Introducción: La distribución de la grasa corporal ha sido asociada significativamente como elemento de predicción del factor de riesgo de enfermedades cardiovasculares. El objetivo del estudio fueron verificar la aplicabilidad de los índices antropométricos estaturo-ponderales (Índice de masa corporal IMC e índice de masa triponderal IMT) para valorar la adiposidad corporal en jóvenes estudiantes universitarios peruanos. Material y métodos: Se efectuó un estudio descriptivo (correlacional) en jóvenes universitarios. Se investigaron 210 sujetos de ambos sexos (59 varones y 151 mujeres) con un rango de edad de 18 a 25 años de una universal nacional de Arequipa. Se evaluó e peso, la estatura y cuatro pliegues cutáneos (bicipital, tricipital, subescapular y supra iliaco). Se calculó el índice de masa corporal IMC e índice triponderal (IMT). Resultados: Las relaciones entre índices antropométricos con la sumatoria de 4 pliegues cutáneos fueron significativas en ambos sexos. En varones, la relación entre sumatoria de pliegues con IMC fue de R2= 75% y con el IMT fue de R2= 73%. En mujeres, la relación de sumatoria de pliegues con el IMC fue de R2= 63% y con el IMT de R2= 57%. Hubo diferencias significativas entre las tres categorías (alto, medio y bajo), tanto para IMC, como para IMT y en ambos sexos (p<0,05). Conclusión: En ambos sexos, se observó una asociación significativa entre el IMC y el IMT con el sumatorio de pliegues subcutáneos. Estos hallazgos sugieren que tanto el IMC como el IMT resultan útiles para estimar adiposidad corporal en estudiantes universitarios peruanos. (AU)

Introduction: Body fat distribution has been significantly associated as a predictor of cardiovascular disease risk factor. The aim of the study was to verify the applicability of the anthropometric staturo-weight indices (Body Mass Index BMI and Triponderal Mass Index TMI) to assess body adiposity in young Peruvian university students. Material and methods: A descriptive (correlational) study was carried out in young university students. We investigated 210 subjects of both sexes (59 males and 151 females) with an age range of 18 to 25 years from a national university in Arequipa. Weight, height and four skinfolds (bicipital, tricipital, subscapular and supra iliac) were evaluated. Body mass index (BMI) and triponderal index (TMI) were calculated. Results: The relationships between anthropometric indices and the sum of 4 skinfolds were significant in both sexes. In men, the relationship between the sum of skinfolds with BMI was R2= 75% and with the TMI was R2= 73%. In females, the relationship between the sum of folds with BMI was R2= 63% and with TMI was R2= 57%. There were significant differences between the three categories (high, medium and low), both for BMI and TMI and in both sexes (p<0.05). Conclusion: In both sexes, there was a significant association between BMI and IMT with the sum of subcutaneous folds. These findings suggest that both BMI and TMI are useful to estimate body adiposity in Peruvian university students. (AU)

Novel TRPV1 Channel Agonists With Faster and More Potent Analgesic Properties Than Capsaicin.

The transient receptor potential vanilloid 1 (TRPV1) ion channel is a member of the family of Transient Receptor Potential (TRP) channels that acts as a molecular detector of noxious signals in primary sensory neurons. Activated by capsaicin, heat, voltage and protons, it is also well known for its desensitization, which led to the medical use of topically applied TRPV1 agonist capsaicin for its long-lasting analgesic effects. Here we report three novel small molecules, which were identified using a Structure-Based Virtual Screening for TRPV1 from the ZINC database. The three compounds were tested using electrophysiological assays, which confirmed their capsaicin-like agonist activity. von Frey filaments were used to measure the analgesic effects of the compounds applied topically on tactile allodynia induced by intra-plantar carrageenan. All compounds had anti-nociceptive activity, but two of them showed faster and longer lasting analgesic effects than capsaicin. The present results suggest that TRPV1 agonists different from capsaicin could be used to develop topical analgesics with faster onset and more potent effects.