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Cell Mol Biol (Noisy-le-grand) ; 56(2): 44-6, 2010 May 10.
Article in English | MEDLINE | ID: mdl-20525459

ABSTRACT

The aim of the present work is to propose a protocol for quantification of (18)F-FDG activities at organ level through whole body exams with Positron Emission Tomography. They were selected patients with normal uptake or a single tumor. In the period 2004-2005, 745 patients were studied. Among then, it was selected 97 adults for the normal uptake control group. The main studies were: intestine; colon, rectum, lung, lymphoma and melanoma, liver, esophagus, gonads and breasts. For "prospective screening", it were selected 20 patients with the identical physical characteristics of the control group. For internal dosimetry, the main organs should be elected according the kinetics of (18)F-FDG, either considering normal uptake or pathologies. Absorbed doses due to Computed Tomography and F-FDG uptake were estimated. Comparisons between internal and external exposures, for the same organ, point out higher doses due to external irradiation, except for bladder and kidneys. For individual dose estimation, parameters such the effective half-life should be known and this information may be achieved by an adaptation of the routine protocol.


Subject(s)
Fluorodeoxyglucose F18/analysis , Multimodal Imaging/methods , Positron-Emission Tomography/methods , Radiometry/methods , Tomography, X-Ray Computed/methods , Adolescent , Adult , Brain/diagnostic imaging , Female , Humans , Kinetics , Male , Middle Aged , Young Adult
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