ABSTRACT
Blue nevus is a benign melanocytic lesion, typically asymptomatic and of unknown etiology. Many histological subtypes are recognized, the most commons being: common blue nevus, cellular blue nevus, and combined blue nevus. New rare variants have been described in the literature, with emphasis on eruptive blue nevus, plaque, agminate, linear, with satellitosis, disseminated, familial and targetoid. The diagnosis of blue nevus usually presents no difficulties, however, the presence of structures such as irregular edges or satellitosis, are highly suggestive of malignancy, and the differential diagnosis with malignant blue nevus and melanoma with peripheral spread should be considered. We report a case of blue nevus with satellitosis in a 15-year-old female patient.
Subject(s)
Nevus, Blue/pathology , Skin Neoplasms/pathology , Adolescent , Biopsy , Dermoscopy , Diagnosis, Differential , Female , Humans , Melanocytes/pathology , Melanoma/pathologyABSTRACT
Abstract: Blue nevus is a benign melanocytic lesion, typically asymptomatic and of unknown etiology. Many histological subtypes are recognized, the most commons being: common blue nevus, cellular blue nevus, and combined blue nevus. New rare variants have been described in the literature, with emphasis on eruptive blue nevus, plaque, agminate, linear, with satellitosis, disseminated, familial and targetoid. The diagnosis of blue nevus usually presents no difficulties, however, the presence of structures such as irregular edges or satellitosis, are highly suggestive of malignancy, and the differential diagnosis with malignant blue nevus and melanoma with peripheral spread should be considered. We report a case of blue nevus with satellitosis in a 15-year-old female patient.
Subject(s)
Humans , Female , Adolescent , Skin Neoplasms/pathology , Nevus, Blue/pathology , Biopsy , Dermoscopy , Diagnosis, Differential , Melanocytes/pathology , Melanoma/pathologyABSTRACT
Contexto: A ciclosporina é um potente imunossupressor que age primariamente nas células T por meio da inibição da calcineurina e consequente inibição da transdução do sinal mediada pela ativação do receptor das células T, sendo considerada por muitos como terapia de escolha nos casos de dermatite atópica grave. Descrição do caso: Relata-se o caso de paciente com dermatite atópica grave submetido a tratamento com ciclosporina que apresentou, em sua evolução, diagnóstico de melanoma in situ do tipo extensivo superficial. Discussão: Um dos efeitos colaterais mais graves do uso de ciclosporina é o aumento do risco de câncer, incluindo o desenvolvimento de lesões pré-malignas e tumores cutâneos malignos em áreas de pele expostas à luz solar, particularmente carcinomas de células escamosas. Conclusões: Há eficácia da ciclosporina na terapêutica de dermatite atópica grave, porém, pacientes que fazem uso desta droga devem ser submetidos rotineiramente a cuidadoso exame dermatológico à procura de qualquer sinal de neoplasia cutânea.
