ABSTRACT
Inflammatory bowel disease (IBD) is a multifactorial chronic disease, commonly associated with alteration in the composition and function of gut microbiota. This process can lead to a decreased production of short chain fatty acids (SCFAs) by the gut microbiota, mainly butyrate, which is an important immunomodulatory molecule in the intestine. Butyrogenic bacteria normally produces butyrate through carbohydrate fermentation or amino acids degradation pathways. This molecule plays an important protective role in intestinal homeostasis acting in both adaptive immunity and innate immunity. This review summarizes the current knowledge about the role of butyrate on the development of IBD and the protective mechanisms of this metabolite on the intestinal mucosa and the whole body, as reported by in vitro and in vivo studies. Thus, butyrate can regulate the activation of regulatory T cells, increasing the acetylation of histones and decreasing the activation of NF-κB. In addition, it can also stimulate the mucus production from epithelial cells and the rearrangement of tight junction proteins.
Subject(s)
Butyrates/therapeutic use , Inflammatory Bowel Diseases/drug therapy , Protective Agents/therapeutic use , Humans , Inflammatory Bowel Diseases/metabolism , Inflammatory Bowel Diseases/pathologyABSTRACT
Este estudo teve como objetivo realizar uma revisão sistemática da literatura para avaliar os efeitos dos hábitos parafuncionais de sucção sobre a ATM e estruturas adjacentes em crianças. Os artigos incluídos foram identificados por meio de pesquisas bibliográficas da Bireme, Pubmed, ClinicalTrials.gov, The National Research Register e Pro-Quest Dissertation Abstracts and Thesis, usando os termos de busca temporomandibular joint, sucking behavior and fingersucking. As pesquisas sobre os hábitos atuais ou anteriores de chupar o dedo e/ou uso de mamadeiras e chupetas e a presença de dor na ATM com crianças até 12 anos foram incluídas. Oito estudos foram selecionados, e 4 apresentaram uma associação, mas sem significância estatística. Os achados científicos demonstram uma associação baixa ou ausente de DTM com hábitos de sucção parafuncionais.
Objective: To assess the attitudes and knowledge about hepatitis by scholars and dental practitioners from Recife and its metropolitan region. Method: The research protocol was submitted and approved by the Ethics and Human Research Committee of the Federal University of Pernambuco. There were included 230 undergraduate students in dentistry and 104 dentists who exercise their professional activity in Recife and its Metropolitan Region. They signed a consent form and answered a questionnaire, the evaluative instrument, with objective questions about biosafety, transmission of hepatitis and sexually transmitted diseases. Results: About the types of hepatitis 133 (57.8%) students and 61 (58.7%) professionals claimed to know the types A, B and C. Concerning transmission 31 (13.5%) students and 25 (24.0%) professionals said that the main route of transmission were sexual and bloodstream respectively. Relating to imunization 221 (96.1%) students and 99 (95.2%) professionals reported that have been vaccinated against hepatitis B, however, only 126 (54.8%) students and 55 (52.9%) professionals have followed the immunization's schema. Regarding the cleaning of the office equipment, 18.7% of the students replied that they do not know who does it. 56.7% of professionals said that it was performed with alcohol 70 ° GL.Conclusions: The findings indicate that there is a concern for biosafety but the knowledge about the forms of hepatitis transmission and biosecurity measures need to be better settled.
