ABSTRACT
OBJECTIVE: To evaluate the behavior of acute phase proteins and lipid profile in patients undergoing Roux-en-Y gastric bypass. METHODS: We conducted a prospective study, consisting of three moments: M1 - preoperative (24 hours before surgery); M2 - 30 days after surgery; and M3 - 180 days after surgery. We carried measured height and BMI, as well as determined the concentrations of acute phase proteins (C-reactive protein (CRP), albumin and Alpha-1-acid glycoprotein) and total cholesterol, LDL-c, HDL-c and triacylglycerol. RESULTS: participants comprised 25 individuals, with a mean age of 39.28 ± 8.07, 72% female. At all times of the study there was statistically significant difference as for weight loss and BMI. We found a significant decrease in CRP concentrations between the moments M1 and M3 (p = 0.041) and between M2 and M3 (p = 0.018). There was decrease in Alpha-1-GA concentrations between M1 and M2 (p = 0.023) and between M1 and M3 (p = 0.028). The albumin values increased, but did not differ between times. Total cholesterol and triacylglycerol decreased significantly ay all times. LDL-c concentrations decreased and differed between M1 and M2 (p = 0.001) and between M1 and M3 (p = 0.001). HDL-c values increased, however only differing between M1 and M2 (p = 0.050). CONCLUSION: Roux-en-Y gastric bypass promoted a decrease in plasma concentrations of CRP and Alpha-1-acid glycoprotein, improving lipid and inflammatory profiles.
Subject(s)
Gastric Bypass , Lipids/blood , Obesity, Morbid/surgery , Adult , C-Reactive Protein/analysis , Female , Humans , Male , Middle Aged , Prospective Studies , Weight LossABSTRACT
Objective: To evaluate the behavior of acute phase proteins and lipid profile in patients undergoing Roux-en-Y gastric bypass. Methods : We conducted a prospective study, consisting of three moments: M1 - preoperative (24 hours before surgery); M2 - 30 days after surgery; and M3 - 180 days after surgery. We carried measured height and BMI, as well as determined the concentrations of acute phase proteins (C-reactive protein (CRP), albumin and Alpha-1-acid glycoprotein) and total cholesterol, LDL-c, HDL-c and triacylglycerol. Results : participants comprised 25 individuals, with a mean age of 39.28 ± 8.07, 72% female. At all times of the study there was statistically significant difference as for weight loss and BMI. We found a significant decrease in CRP concentrations between the moments M1 and M3 (p = 0.041) and between M2 and M3 (p = 0.018). There was decrease in Alpha-1-GA concentrations between M1 and M2 (p = 0.023) and between M1 and M3 (p = 0.028). The albumin values increased, but did not differ between times. Total cholesterol and triacylglycerol decreased significantly ay all times. LDL-c concentrations decreased and differed between M1 and M2 (p = 0.001) and between M1 and M3 (p = 0.001). HDL-c values increased, however only differing between M1 and M2 (p = 0.050). Conclusion : Roux-en-Y gastric bypass promoted a decrease in plasma concentrations of CRP and Alpha-1-acid glycoprotein, improving lipid and inflammatory profiles.
Objetivo: avaliar o comportamento das proteínas de fase aguda e o perfil lipídico em pacientes submetidos à derivação gástrica em Y-de-Roux. Métodos: estudo prospectivo, constituído por três momentos: M1 - pré-cirúrgico (24 horas antes do procedimento cirúrgico); M2 - 30 dias pós-cirúrgico; e M3 - 180 dias pós-cirúrgico. Foram realizadas aferição antropométrica de peso, altura e IMC, como também determinação das concentrações das proteínas de fase aguda (proteína c reativa (PCR), albumina e alfa-1-glicoproteína-ácida) e de colesterol total, LDL-c, HDL-c e triacilglicerol. Resultados: participaram desse estudo 25 indivíduos, com média de idade de 39,28±8,07, sendo 72% do sexo feminino. Em todos os momentos do estudo observou-se diferença estatística significativa quanto à redução de peso e IMC. Verificou-se diminuição com diferença nas concentrações da PCR entre os momentos M1 e M3 (p=0,041); M2 e M3 (p=0,018). As concentrações da a1-GA reduziram e foram diferentes entre os momentos M1 e M2 (p=0,023); M1 e M3 (p=0,028). Os valores de albumina aumentaram, mas não diferiram entre os momentos. O colesterol total e o triacilglicerol diminuíram com diferença entre todos os momentos. As concentrações de LDL-c diminuíram e diferiram entre os momentos M1 e M2 (p=0,001); M1 e M3 (p=0,001). Os valores de HDL-c aumentaram, entretanto apenas diferiram entre os momentos M1 e M2 (p=0,050). Conclusão: a derivação gástrica em Y-de-Roux promoveu diminuição nas concentrações plasmáticas da PCR e alfa-1-glicoproteína ácida, melhorando o perfil inflamatório e lipídico.
Subject(s)
Humans , Male , Female , Adult , Obesity, Morbid/surgery , Gastric Bypass , Lipids/blood , C-Reactive Protein/analysis , Weight Loss , Prospective Studies , Middle AgedABSTRACT
Objetivo: Analizar la influencia de los factores internos y externos (Fortalezas, Oportunidades, Debilidades y Amenazas) durante el proceso de cambio de turno, según la óptica de profesionales de enfermería del Hospital Universitario de Sergipe, Brasil. Método: Investigación de tipo descriptiva-exploratoria con enfoque cuantitativo utilizando el planeamiento estratégico como fundamento teórico, así como la construcción de la Matriz de Fortalezas, Oportunidades, Debilidades y Amenazas (FODA). Los datos fueron recolectados a través de cuestionario previamente elaborado. Resultados: Tipos de pasaje de turno encontrados: entre profesionales de la misma categoría, a través del libro, en la unidad del paciente. Fortalezas: duración máxima de 15 a 20 minutos, objetividad en las informaciones y cooperación del equipo. Debilidades: funcionarios apresurados para salir, impuntualidad para inicio y atraso de los colegas. Oportunidades: relación efectiva con otros profesionales, la gerencia hospitalaria y los nuevos modelos de gestión implantados en la institución. Amenazas: llamadas telefónicas durante el cambio de turno, exceso de unidades bajo responsabilidad de los profesionales. Se elaboró también la matriz estratégica FODA. Conclusiones: Posterior al estudio sistemático de los factores internos e externos fue posible proponer alternativas capaces de contribuir en la gestión del cuidado(AU)
Objective: To analyze the influence of the internal and external factors (Strengths, Opportunities, Weakness and Threatens) during the process of shift change, according to the view of nursing professionals at the University Hospital of Segirpe, Brasil. Method: Descriptive-exploratory research, with a quantitative approach using the strategy plan, as a theoretical basis, as much as the building of the Strengths, Opportunities, Weakness and Threatens matrix (SOWTM). Data were collected through a previous elaborated questionnaire. Results: Types of shift change that were found: among professionals of the same category, by means of the book, in the unit of the patient. Strengths: maximum duration from 15 to 20 minutes, objective information and team co-operation. Weakness: civil servants in a hurry because they wanted to go home, lack of punctuality to start and delay of the colleagues. Opportunities: effective relations with other professionals, the hospital management and the new models of administration settled in the institution. Threatens: Phone calls during the shift change and too many units under the professionals responsibility. The strategy matrix (SOWTM) was also elaborated. Conclusions: After the systematic study of the internal and external factors, it was possible to propose alternatives that could contribute to the care management(AU)
