ABSTRACT
In this work, the effect of different solvents and solvent binary mixtures on the morphology of electrospun pullulan (Pull) nanofibers was evaluated. The solution viscosities, interactions between solvent and polymer, as well as, solvent vapor pressure, were correlated to the morphology and diameters of the nanofibers. Water, dimethylformamide (DMF) and dimethyl sulfoxide (DMSO) and Teas graphs that rely on the use of Hildebrand solubility parameters were used to identify the most suitable mixtures of solvents. The best binary mixture of solvents to produce Pull nanofibers without defects and with small diameters (203±32 nm) was DMF/DMSO in the ratio of 70/30 wt.%. Pull nanofibers containing 3 and 5 wt. % of curcumin (Curc) in a mixture of DMF/DMSO (70/30 wt.%) were then obtained, and the entrapment efficiency was evaluated using 1H NMR and a UV--vis spectrophotometer. The results obtained in this work create a new approach for the production of Pull nanofibers for drug delivery systems.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/chemistry , Curcumin/chemistry , Drug Delivery Systems , Electrochemistry/methods , Glucans/chemistry , Nanofibers/chemistry , Solvents/chemistry , Molecular Conformation , SolubilityABSTRACT
Os autores apresentam os resultados de 41 pacientes com complicaçöes de tratamento de fraturas diafisárias dos ossos do antebraço. Analisam as lesöes de ambos os ossos ou de ossos isolados e o tipo de complicaçäo, apresentando as várias opçöes de tratamento partindo de um conceito básico, com o objetivo de restabelecer a continuidade óssea e melhorar a funçäo da mäo. Concluem que näo existe padronizaçäo do tratamento das complicaçöes e cada caso deve merecer estudo especial e conduta específica; porém, qualquer que seja o método, o importante é prover estabilizaçäo rígida dos focos fraturados. Em casos especiais, o movimento de pronossupinaçäo dos dois ossos do antebraço deve ser sacrificado em favor da funçäo da mäo.
