Comparison of pelvic floor muscle training isolated and associated with weight loss: a randomized controlled trial.

PURPOSE: To analyze whether pelvic floor muscle training (PFMT) associated with weight loss (WL) is better than isolated PFMT to provide additional beneficial effects to urinary symptoms in women with MUI. METHODS: A randomized, simple-blind parallel controlled trial was performed and included women with MUI aged between 40 and 65 years and body mass index between 25 and 40 kg/m2. The sample was randomized into two groups: 11 PFMT + WL and 11 PFMT. Data collection was performed in baseline and after interventions. The primary outcome was to investigate the loss of urine. Secondary aim includes PFM pressure and quality of life. PFMT was performed with two sets of eight repetitions in the first 4 weeks, and with three sets of eight repetitions in the final 4 weeks. The weight loss program was based on the calculation of total energy value needs. Data analysis was performed by SPSS 20.0 software and one-way ANCOVA. RESULTS: 22 volunteers participated in the study. There was no intergroup significant difference in post-intervention ICIQ-SF F(1, 19) = 7.115, p = 0.87, partial η2 = 0.001; manometry F(1, 19) = 0.608, p = 0.44, partial η2 = 0.003; pad test 1 h F(1, 19) = 0.185, p = 0.67, partial η2 = 0.01; QoL F(1, 19) = 1.018, p = 0.32, partial η2 = 0.05; and weight F(1, 19) = 0.251, p = 0.62, partial η2 = 0.01. CONCLUSIONS: Weight loss did not provide additional beneficial effects to PFMT in women with overweight or obesity grade I with MUI symptoms.

Gastroprotective and antielastase effects of protein inhibitors from Erythrina velutina seeds in an experimental ulcer model.

Trypsin and chymotrypsin inhibitors from Erythrina velutina seeds have been previously isolated by our group. In previous studies using a sepsis model, we demonstrated the antitumor and anti-inflammatory action of these compounds. This study aimed to evaluate the gastroprotective and antielastase effects of protein inhibitors from E. velutina seeds in an experimental stress-induced ulcer model. Two protein isolates from E. velutina seeds, with antitrypsin (PIAT) and antichymotrypsin (PIAQ) activities, were tested. Both protein isolates showed a high affinity and inhibitory effect against human neutrophil elastase, with 84% and 85% inhibition, respectively. Gastric ulcer was induced using ethanol (99%) in 6 groups of animals (female Wistar rats, n = 6). Before ulcer induction, these animals were treated for 5 days with one of the following: (1) PIAT (0.2 mg·kg-1), (2) PIAT (0.4 mg·kg-1), (3) PIAQ (0.035 mg·kg-1), (4) ranitidine hydrochloride (50 mg·kg-1), (5) saline solution (0.9%), or (6) no intervention (sham). Both PIAT and PIAQ protected gastric mucosa, preventing hemorrhagic lesions, edema, and mucus loss. No histologic toxic effects of PIAT or PIAQ were seen in liver and pancreatic cells. Our results show that protein isolates from E. velutina seeds have potential gastroprotective effects, placing these compounds as natural candidates for gastric ulcer prevention.

Abandonment to therapeutic diet on patients at risk cardiovascular in a health care clinic.

BACKGROUND: Cardiovascular diseases are the leading cause of death among adults and measures to reverse this situation go through changes in lifestyle, among them adopt healthy eating through professional counseling. To do this we need to keep the patient engaged in treatment, and the abandonment of treatment is an important risk factor in this population. OBJECTIVES: To assess abandonment to dietary treatment of patients with cardiovascular risk treated on an outpatient basis, and identify the reasons for the abandonment of treatment. METHODS: Participants were patients between 18 and 70 years, of both sexes, who held their first nutritional consultation and had two or more cardiovascular risk factors. A telephone contact was made by applying a questionnaire on the withdrawal of reasons for treatment and encouraging them to return to the health service by checking the return after three months of telephone contact. RESULTS: Of the 142 patients with cardiovascular risk, 61.26% did not return to the service after the first visit, a percentage similar to that found in other studies, and contacted by telephone 64.37% of them. Regarding the main reasons for the withdrawal, difficulty following the diet and individual/behavioral characteristics of the patient were the aspects that contributed to the abandonment (57.14%), corroborating the findings that show the influence of cultural and socioeconomic factors on the therapeutic adherence. Although 92.86% of patients have been satisfied with the service and 75% have reported interest in resuming treatment, only 5.36% patients returned to service after the phone contact. CONCLUSION: There was a high drop-out from nutritional treatment, mainly because of the difficulty of organization required to follow the diet. The motivational intervention was not enough to motivate a return to treatment.