ABSTRACT
Publication from 2006, republished on 2009 about how to promote better treatment of victims and their families. It includes controle of diseases, how to deal with the bodies, about communication and support to families. It also includes annexes. Document in pdf format; 54 pages.
Subject(s)
Cadaver , Communicable Disease Control , Victims Identification , Social Support , Social Communication in Emergencies , Mortuary Practice , Mass Casualty IncidentsABSTRACT
AT-1002 a 6-mer synthetic peptide belongs to an emerging novel class of compounds that reversibly increase paracellular transport of molecules across the epithelial barrier. The aim of this project was to elaborate on the structure-activity relationship of this peptide with the specific goal to replace the P2 cysteine amino acid. Herein, we report the discovery of peptides that exhibit reversible permeability enhancement properties with an increased stability profile.
Subject(s)
Chemistry, Pharmaceutical/methods , Oligopeptides/pharmacology , Peptides/chemistry , Amino Acids/chemistry , Biological Transport , Caco-2 Cells , Cell Survival , Chromatography, High Pressure Liquid , Cysteine/chemistry , Drug Delivery Systems , Drug Design , Humans , Models, Chemical , Permeability , Structure-Activity RelationshipABSTRACT
The implementation of [13Calpha,13C',15N,2Halpha] labelled amino acids into proteins allows the acquisition of high resolution triple resonance experiments. We present for the first time resonance assignments facilitated by this new labelling strategy. The absence of 1JCalpha,Cbeta couplings enables us to measure 1JCalpha,C' scalar and 1DCalpha,C' residual dipolar coupling constants using modified HNCA experiments which do not suffer from sensitivity losses characteristic for 13C constant time experiments.
