Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 49
Filter
1.
Sci Adv ; 5(8): eaau9309, 2019 08.
Article in English | MEDLINE | ID: mdl-31453319

ABSTRACT

Malignant brain neoplasms have a poor prognosis despite aggressive treatments. Animal models and evidence from human bodily tumors reveal that sustained reduction in tumor perfusion via electrical stimulation promotes tumor necrosis, therefore possibly representing a therapeutic option for patients with brain tumors. Here, we demonstrate that transcranial electrical stimulation (tES) allows to safely and noninvasively reduce intratumoral perfusion in humans. Selected patients with glioblastoma or metastasis underwent tES, while perfusion was assessed using magnetic resonance imaging. Multichannel tES was applied according to personalized biophysical modeling, to maximize the induced electrical field over the solid tumor mass. All patients completed the study and tolerated the procedure without adverse effects, with tES selectively reducing the perfusion of the solid tumor. Results potentially open the door to noninvasive therapeutic interventions in brain tumors based on stand-alone tES or its combination with other available therapies.


Subject(s)
Brain Neoplasms/therapy , Glioblastoma/therapy , Transcranial Direct Current Stimulation/methods , Aged , Antineoplastic Agents/therapeutic use , Cerebrovascular Circulation/physiology , Combined Modality Therapy , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged
2.
G Chir ; 35(7-8): 195-8, 2014.
Article in English | MEDLINE | ID: mdl-25174296

ABSTRACT

AIM: To report on our routine use of TachoSil® for dural repair in neurosurgical practice. METHOD: TachoSil® has been applied in different fields of surgery thus far. When using TachoSil®, fibrinogen and thrombin is provided locally at the site of the dural defects. Upon contact with fluid, the clotting factors of TachoSil® dissolve and form a fibrin network, which glues the collagen sponge to the wound surface. RESULTS: In our experience, TachoSil® was found to be effective as support for the suture of the dura in patients undergoing spinal and cranial neurosurgical operations. Two illustrative examples are shown. CONCLUSIONS: Our procedure showed that closing the dural defect with TachoSil® is a technically simple, reliable and safe method for patients. Indeed, no post-operative cerebrospinal fluid leakage was observed. Nonetheless, further studies with larger sample size are warranted to confirm the efficacy of TachoSil® patches for dural repair.


Subject(s)
Brain Ischemia/surgery , Dura Mater/surgery , Fibrinogen , Meningeal Neoplasms/surgery , Meningioma/surgery , Neurosurgical Procedures , Thrombin , Aged , Drug Combinations , Female , Humans , Male , Middle Aged , Wound Healing
3.
Opt Lett ; 37(10): 1760-2, 2012 May 15.
Article in English | MEDLINE | ID: mdl-22627562

ABSTRACT

Within the range of validity of the Rytov approximation (RA), an innovative Bayesian compressive sensing (BCS) inverse scattering technique is developed. Potentialities and limitations of the BCS-RA method are validated through numerical experiments and representative results are discussed.

4.
J Neurosurg Sci ; 55(2): 89-92, 2011 Jun.
Article in English | MEDLINE | ID: mdl-21623320

ABSTRACT

Starting from January 2008, we systematically irrigated the surgical wounds of patients undergoing spine surgery with a solution of povidone-iodine and hydrogen peroxide. We prospectively recorded the clinical data of patients who underwent spine surgery during 2008 and we compared the results with retrospectively reviewed clinical records of patients operated during 2007. Patients were analyzed for preoperative risk factors, type of surgical procedure, onset of infection, presentation, treatment and outcome. We performed 490 spine surgeries during 2008 and 460 during 2007. We recorded four postoperative infections in 2007 compared to none in 2008. We consider this solution of povidone-iodine plus hydrogen peroxide effective to further reduce the rate of post-operative infection in spine surgery.


Subject(s)
Anti-Infective Agents, Local/administration & dosage , Hydrogen Peroxide/administration & dosage , Povidone-Iodine/administration & dosage , Spinal Diseases/surgery , Surgical Wound Infection/prevention & control , Anti-Infective Agents, Local/adverse effects , Humans , Hydrogen Peroxide/adverse effects , Povidone-Iodine/adverse effects , Retrospective Studies , Solutions/administration & dosage , Therapeutic Irrigation/methods
5.
G Chir ; 32(3): 118-9, 2011 Mar.
Article in English | MEDLINE | ID: mdl-21453589

ABSTRACT

Spheno-orbital meningioma have traditionally been defined as secondary tumors of the orbit originating from the dura of the sphenoid wing bone. Nevertheless, pathologic findings reveal a distinct periorbital component as a defining feature of these lesions. These tumors are characterized by an intraosseous mass growth leading to a significant hyperostosis involving the sphenoid wing, the orbital roof, the lateral orbital wall and the middle fossa cranial base and to a thin, usually soft-tissue growth at the dura. We report here on the extension of the primary tumor into the orbital cavity and present the surgical approach performed.


Subject(s)
Meningioma/surgery , Orbital Neoplasms/surgery , Female , Humans , Middle Aged , Osteotomy/methods
6.
G Chir ; 31(10): 456-8, 2010 Oct.
Article in English | MEDLINE | ID: mdl-20939955

ABSTRACT

CASE REPORT: A 70-years-old woman presented with a one week history of progressive loss of vision in the right eye (RE) diagnosed as retinal detachment from 7 to 1 o' clock with retinal break at the 10.30 o' clock associated. Gadolinium enhanced magnetic resonance imaging (MRI) scan of the brain and orbits with fat suppression showed a convexity meningioma. Scleral buckling with a segmental sponge, subretinal fluid drainage and cryopexy were performed with detachment repair. CONCLUSION: In our patient with retinal detachment and convexity meningioma without significant neurological symptoms, performing ocular surgery and close follow up care seemed to be the optimal treatment option.


Subject(s)
Meningeal Neoplasms/complications , Meningioma/complications , Retinal Detachment/complications , Aged , Female , Humans
7.
G Chir ; 31(10): 459-61, 2010 Oct.
Article in English | MEDLINE | ID: mdl-20939956

ABSTRACT

The authors report their surgical experience with 10 cases of anterior subcutaneous ulnar nerve transposition and coverage of the nerve with substitutive dural flap, performed between January and November 2008 at the Department of Neurosurgery ("Santa Maria alle Scotte" Hospital, Siena, Italy) in the treatment of severe cubital tunnel syndrome. Clinical long-term results are analyzed and the relevant literature is reviewed.


Subject(s)
Cubital Tunnel Syndrome/surgery , Ulnar Nerve , Aged , Female , Humans , Male , Middle Aged , Neurosurgical Procedures/methods , Prostheses and Implants , Severity of Illness Index , Time Factors , Treatment Outcome
8.
G Chir ; 31(8-9): 368-70, 2010.
Article in English | MEDLINE | ID: mdl-20843438

ABSTRACT

Rosette-forming glioneuronal tumour (RGNT) of the fourth ventricle is a relatively new entity recently described. Neuronal and mixed neuronal-glial tumours have been incorporated in the same category in the WHO Classification of Nervous System Tumours. This category comprises heterogeneous neoplasms composed of neuronal and glial cells with various grades of differentiation. We present a case of papillary glioneuronal tumor occurring in a 44-year-old man with an unusual hemorrhagic onset. The clinical, morphological and immunohistochemical features are discussed and the published literature is reviewed.


Subject(s)
Cerebral Ventricle Neoplasms/diagnosis , Ganglioglioma/diagnosis , Neoplasms, Complex and Mixed/diagnosis , Adult , Cerebral Ventricle Neoplasms/surgery , Craniotomy , Diagnosis, Differential , Ganglioglioma/surgery , Humans , Male , Neoplasms, Complex and Mixed/surgery , Prognosis , Treatment Outcome
9.
G Chir ; 31(5): 247-50, 2010 May.
Article in English | MEDLINE | ID: mdl-20615370

ABSTRACT

The authors report their surgical experience on 50 patients affected by single or two level segmental lumbar canal stenosis who underwent implantation of one or two X-Stop interspinous devices between October 2007 and February 2008 at the Department of Neurosurgery, "Santa Maria alle Scotte" Hospital, Siena, Italy. In the present study there will be analyzed clinical long-term results and reviewed the relevant literature.


Subject(s)
Intermittent Claudication/surgery , Internal Fixators , Lumbar Vertebrae/surgery , Spinal Fusion/instrumentation , Spinal Stenosis/surgery , Adult , Aged , Decompression, Surgical/methods , Female , Follow-Up Studies , Humans , Intermittent Claudication/diagnosis , Intermittent Claudication/etiology , Length of Stay , Lumbar Vertebrae/pathology , Male , Middle Aged , Patient Satisfaction , Patient Selection , Prostheses and Implants , Retrospective Studies , Spinal Fusion/methods , Spinal Stenosis/complications , Spinal Stenosis/diagnosis , Surveys and Questionnaires , Treatment Outcome
10.
G Chir ; 31(4): 159-61, 2010 Apr.
Article in English | MEDLINE | ID: mdl-20444333

ABSTRACT

Idiopatic pseudotumor (IP) is a non-specific, non-neoplastic, inflammatory process without identifiable local or systemic causes. IP most commonly affects the orbit, comprising 5% to 8% of all orbital masses with occasional extension to other areas of the skull base. The ophthalmology literature has detailed reviews of IP as a space-occupying intraorbital lesion, but lesion involving only the skull base and sparing the orbit is exceptional. Understanding the presentation, work-up, and characteristics of the lesion is important for proper diagnosis and treatment. We report a rare case of orbital IP with extension into infratemporal fossa. Clinical and radiological findings and surgical approach are discussed.


Subject(s)
Maxillary Diseases/etiology , Orbital Pseudotumor/complications , Aged , Female , Humans
11.
Pathologica ; 101(1): 12-4, 2009 Feb.
Article in English | MEDLINE | ID: mdl-19771766

ABSTRACT

Meningiomas without dural connection are rare lesions and often referred to as ectopic. Primary ectopic intraosseous meningiomas are uncommon, accounting for less than 2% of all meningiomas. Herein the authors describe a case of meningioma involving the frontal bone in a 43-year-old man and review the relevant literature.


Subject(s)
Bone Neoplasms/diagnosis , Meningioma/diagnosis , Adult , Bone Neoplasms/pathology , Bone Neoplasms/surgery , Craniotomy , Humans , Male , Meningioma/pathology , Meningioma/surgery , Skull
12.
G Chir ; 30(3): 109-11, 2009 Mar.
Article in English | MEDLINE | ID: mdl-19351462

ABSTRACT

Several complications are known to occur with spinal anaesthesia and all of them are easily recognizable. We report the case of a 25 year old woman presenting with intracerebral hemorrhage secondary to spinal anaesthesia for caesarean section. She underwent surgical evacuation of the haematoma with complete recovery. The relevant literature is also reviewed.


Subject(s)
Anesthesia, Spinal/adverse effects , Cesarean Section , Hematoma, Subdural, Intracranial/etiology , Hematoma, Subdural, Intracranial/surgery , Adult , Female , Headache/etiology , Hematoma, Subdural, Intracranial/diagnosis , Hemiplegia/etiology , Humans , Pregnancy , Treatment Outcome
13.
G Chir ; 30(1-2): 51-2, 2009.
Article in English | MEDLINE | ID: mdl-19272234

ABSTRACT

Epidural anesthesia is one of the preferred modes of analgesia intra- and postoperative in limb surgery. Although considered very safe, serious complications can occur with 0.1-1 per 10,000 epidural injections. We present a case of a patient who experienced an acute lumbar epidural hematoma after epidural anesthesia.


Subject(s)
Analgesia, Epidural , Anticoagulants/adverse effects , Enoxaparin/adverse effects , Hematoma, Epidural, Spinal/etiology , Postoperative Complications/etiology , Punctures/adverse effects , Aged, 80 and over , Anticoagulants/therapeutic use , Arthroplasty, Replacement, Knee , Enoxaparin/therapeutic use , Female , Hematoma, Epidural, Spinal/chemically induced , Hematoma, Epidural, Spinal/surgery , Humans , Laminectomy , Magnetic Resonance Imaging , Postoperative Complications/chemically induced , Spinal Cord Compression/etiology , Spinal Cord Compression/surgery
14.
J Neurosurg Sci ; 53(3): 107-11, 2009 Sep.
Article in English | MEDLINE | ID: mdl-20075822

ABSTRACT

AIM: The aim of the study was to assess the efficacy of lumboperitoneal flow-regulated shunt for the treatment of idiopathic intracranial hypertension (IIH). METHODS: This was a retrospective study carried out on four patients with IIH, treated from January to December 2007 with lumboperitoneal flow-regulated shunt (OSV II Smart Valve Systems; Integra NeuroSciences). The mean follow-up period was 13 months. RESULTS: The treatment was successful in alleviating symptoms in all cases and no patient required revisions. CONCLUSIONS: In conclusion the placement of flow-regulated valves is a satisfactory treatment for those IIH patients who require surgical therapy.


Subject(s)
Neurosurgical Procedures/methods , Pseudotumor Cerebri/surgery , Spinal Puncture/methods , Adult , Aged , Female , Humans , Male , Middle Aged , Retrospective Studies
15.
Neurocirugia (Astur) ; 19(5): 453-5, 2008 Oct.
Article in English | MEDLINE | ID: mdl-18936863

ABSTRACT

Solitary eosinophilic granuloma is a rather benign and localized form of Langerhans's cell histiocytosis. Definitive diagnosis is made by histopathology including immunohistochemical detection of S-100, HLA-DR and CD1a antigens. We report the case of a twenty-five year old boy presented with headache and orbit's pain. A CT scan showed a left supero-lateral orbital mass with evidence of bone erosion. The different options of treatment are discussed and the literature is reviewed.


Subject(s)
Histiocytosis, Langerhans-Cell , Orbital Neoplasms , Adult , Biomarkers/metabolism , Histiocytosis, Langerhans-Cell/diagnosis , Histiocytosis, Langerhans-Cell/pathology , Humans , Male , Orbital Neoplasms/diagnosis , Orbital Neoplasms/pathology
16.
Minerva Chir ; 63(5): 421-3, 2008 Oct.
Article in English | MEDLINE | ID: mdl-18923353

ABSTRACT

Herniated thoracic disks are rare entities and their surgical treatment comprises 0.15% to 4% of all disk operations. Surgical approaches have included pediculectomy, costotransversectomy, lateral extracavitary, transthoracic thoracotomy, and thoracoscopy. The authors present a transmanubrial osteomuscular sparing approach for the treatment of T1-T2 thoracic disc herniation that is likely to be the only one described in the literature for this disease so far.


Subject(s)
Intervertebral Disc Displacement/surgery , Manubrium/surgery , Neurosurgical Procedures , Thoracic Vertebrae , Aged , Humans , Intervertebral Disc Displacement/diagnosis , Magnetic Resonance Imaging , Male , Prostheses and Implants , Prosthesis Implantation , Titanium , Tomography, X-Ray Computed , Treatment Outcome
17.
Neurocir. - Soc. Luso-Esp. Neurocir ; 19(5): 453-455, sept.-oct. 2008. ilus
Article in English | IBECS | ID: ibc-61047

ABSTRACT

Solitary eosinophilic granuloma is a rather benignand localized form of Langerhans's cell histiocytosis.Definitive diagnosis is made by histopathology including immunohistochemical detection of S-100, HLA-DR andCD1a antigens. We report the case of a twenty-five year old boy presented with headache and orbit's pain. ACT scan showed a left supero-lateral orbital mass with evidence of bone erosion. The different options of treatment are discussed and the literature is reviewed (AU)


El granuloma solitario eosinófilo es un tumor normalmente benigno y es una forma localizada de la hisitiocitosis de las células de Langerhans. La diagnosis definitiva viene de un estudio histopatológico incluida labúsqueda con métodos inmunohistoquímicos de S-100,HLA-DR y de los antígenos CD1a. Proponemos el casode un joven de venticinco años que presentaba dolor de cabeza y dolor de una órbita. Una TAC muestra unamasa en sede orbital supra-lateral izquierda con unaevidencia de erosión del hueso. Se discuten las diferenteselecciones de tratamiento y se revisa la bibliografia (AU)


Subject(s)
Humans , Male , Adult , Histiocytosis, Langerhans-Cell/diagnosis , Orbital Diseases/diagnosis , Tomography, X-Ray Computed , Histiocytosis, Langerhans-Cell/surgery , Orbital Diseases/surgery , Immunohistochemistry , S100 Proteins/blood , HLA-DR Antigens/blood
18.
Pathologica ; 100(1): 41-2, 2008 Feb.
Article in English | MEDLINE | ID: mdl-18686526

ABSTRACT

Aneurysmal bone cyst is a benign lesion of unknown pathogenesis seen more often in vertebrae and flat bones, and less commonly in the shaft of long bones. Skull involvement is rare and accounts for only 3-6% cases, generally in the first three decades of life. Histologically, the lesion is characterised by the presence of multiple localisations, filled with venous blood and lined by spindle-shaped fibroblasts with scattered multinucleated giant cells and stromal cells. An unusual case of aneurismal bone cyst of the parietal bone is reported.


Subject(s)
Bone Cysts, Aneurysmal/pathology , Parietal Bone , Female , Humans , Middle Aged
19.
G Chir ; 29(5): 233-4, 2008 May.
Article in English | MEDLINE | ID: mdl-18507959

ABSTRACT

Intracerebral haemorrhages occurring after removal of chronic subdural haematoma have been reported as a rare but nearly uniformly devastating postoperative occurrence with incidence ranges between 0,7 and 5%. The absence of a particular attention paid to such complication in literature prompted us to present this report adding our personal experience to the cases already described in the literature.


Subject(s)
Cerebral Hemorrhage/etiology , Cerebral Hemorrhage/surgery , Hematoma, Subdural, Chronic/complications , Hematoma, Subdural, Chronic/surgery , Neurosurgical Procedures/adverse effects , Aged, 80 and over , Cerebral Hemorrhage/diagnostic imaging , Fatal Outcome , Hematoma, Subdural, Chronic/diagnostic imaging , Humans , Male , Postoperative Period , Tomography, X-Ray Computed
20.
G Chir ; 29(3): 79-80, 2008 Mar.
Article in English | MEDLINE | ID: mdl-18366884

ABSTRACT

Capnocytophaga canimorsus has been recognized as an opportunistic pathogen causing systemic infections in immunocompromised individuals. It is part of the normal oral flora of the dog, and can be responsible for localized wound infections in humans in consequence of bites. This microorganism causes also septicemia, meningitis, endocarditis, ocular infections and rarely brain abscess. We describe the case of an immunocompetent 28-year-old male with temporal brain abscess from Capnocytophaga canimorsus secondary to dog's bite.


Subject(s)
Bites and Stings/complications , Brain Abscess/etiology , Capnocytophaga , Dogs , Gram-Negative Bacterial Infections , Adult , Animals , Anti-Bacterial Agents/therapeutic use , Brain Abscess/diagnosis , Brain Abscess/microbiology , Brain Abscess/surgery , Capnocytophaga/isolation & purification , Follow-Up Studies , Gram-Negative Bacterial Infections/surgery , Humans , Magnetic Resonance Imaging , Male , Postoperative Care , Time Factors , Treatment Outcome
SELECTION OF CITATIONS
SEARCH DETAIL
...