ABSTRACT
It is shown that both the reversible Hill equation and a generalised, reversible Monod-Wyman-Changeux equation can give analogous regulatory behaviour when embedded in a model metabolic pathway.
Subject(s)
Coenzymes/chemistry , Models, Chemical , Models, Molecular , Multienzyme Complexes/chemistry , Catalysis , Computer Simulation , Enzyme Activation , Feedback , Substrate SpecificityABSTRACT
This paper shows how Python and Scipy can be used to simulate the time-dependent and steady-state behaviour of reaction networks, and introduces Pysces, a Python modelling toolkit.
Subject(s)
Computer Simulation , Energy Metabolism , Models, Biological , SoftwareABSTRACT
Software to make a database of kinetic models accessible via the internet has been developed and a core database has been set up at http://jjj.biochem.sun.ac.za/. This repository of models, available to everyone with internet access, opens a whole new way in which we can make our models public. Via the database, a user can change enzyme parameters and run time simulations or steady state analyses. The interface is user friendly and no additional software is necessary. The database currently contains 10 models, but since the generation of the program code to include new models has largely been automated the addition of new models is straightforward and people are invited to submit their models to be included in the database.
