Multicentre double-blind clinical trials of ciclopirox olamine cream 1% in the treatment of tinea corporis and tinea cruris.

In separate multicentre, randomized, double-blind clinical trials, 1% ciclopirox olamine cream was compared with its cream vehicle and with 1% clotrimazole cream as treatment for tinea corporis and tinea cruris. Patients who demonstrated clinical and mycological findings consistent with the diagnoses of tinea corporis or tinea cruris were included in the study. Clinical and mycological evaluations were made pretreatment, at the end of each of the four weeks of treatment, and weekly for the two weeks immediately following cessation of treatment. In both studies, use of ciclopirox olamine cream resulted in demonstrable improvements after the first week of therapy and in complete clinical and mycological clearing in two thirds of the patients at the end of the treatment period. These results were maintained through the two-week drug-free observation period that followed the end of treatment. Statistically, the results with ciclopirox olamine cream were significantly better than those with the vehicle and were equivalent to those with clotrimazole cream. All treatments were well tolerated.

[Recessive dystrophic epidermolysis bullosa (with esophageal involvement)]. / Epidermolisis ampollosa distrófica recesiva (con afectación esofágica).

We are presenting a young man with Epidermolysis Bullosa (Dystrophica recessive type) who had lesions in hands, feet and face; some plaques of alopecia were noted on the scalp. Three years ago the patient showed marked dysphagia due to some esophagus erosions, which have been appearing regularly. One year ago it was necessary to take the patient to the Hospital where a esophagectomy was performed replacing the esophagus by a piece of colon.

Human gnathostomiasis in Ecuador (nodular migratory eosinophilic panniculitis). First finding of the parasite in South America.

Fifteen patients with human gnathostomiasis are reported from Ecuador. The name "nodular migratory eosinphilic panniculitis" is proposed because of the histopathologic and clinical changes found in two cases in which the parasite was found on biopsy.

[Lymphomatoid papulosis. The first case reported in Ecuador]. / Papulosis linfomatoide. Primer caso descrito en Ecuador.

We present the first case of lymphomatoid papulosis described in Ecuador. The clinicopathologic aspects of the disease are characteristic and make this entity different deserving its individualization . We discuss the different factors that may have some influence in clinical evolution and prognosis . The case presented is interesting because the lesions have only appeared once. Complete healing was observed after twenty days, and no relapse has been noted since then.

The treatment of dermatophytoses of the glabrous skin: a comparison of undecylenic acid and its salt versus tolnaftate.

In a double-blind study, the efficacy of 1% tolnaftate cream, 3% undecylenic acid and its zinc salt, and a placebo cream were tested in dermatophytosis of the glaborous skin and groin. Ninety-seven subjects completed the study: 33 received tolnaftate, 23 of these subjects were cured clinically and mycologically. Thirty-two subjects received 3% undecylenic acid and 20% zinc undecylenate as a cream. Of these, 21 were cured clinically and mycologically. Only three of the 32 subjects receiving placebo were cured clinically and mycologically. Both tolnaftate and undecylenic acid and its zinc salt are effective in this condition.

[Human gnathostomiasis. The first evidence of the parasite in South America]. / Gnathostomiase humaine. Première mise en évidence du parasite en Amérique du Sud.

Reporting 4 cases of gnathostomiasis, a clinical review of this disease is given by the authors. In one of these cases the diagnosis could be established by evidencing the parasite. The name: nodular migratory eosinophilic panniculitis is suggested for this disease.

[Verruga Peruana in Ecuador. Apropos of 3 cases]. / Verruga peruana en el Ecuador. A propósito de tres casos.

Three cases of Peruvian Verruca, one autoctonous from the town of Guayaquil (Ecuador), are described by the authors. A comparative study with the Peruvian cases is made.