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Am J Perinatol ; 41(8): 1106-1112, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38160676

ABSTRACT

OBJECTIVE: To pilot measurement of hair cortisol concentration (HCC) in pregnant women with opioid use disorder and their infants over time and study the potential utility of hair cortisol as a biomarker of chronic stress in this population. STUDY DESIGN: In this pilot prospective cohort study of mother-infant dyads with and without prenatal opioid exposure, we obtained mother-infant HCCs at delivery and again within 1 to 3 months' postpartum. HCCs were compared between the opioid and control groups and between the two time points. RESULTS: There were no significant differences between opioid and control group maternal or infant HCCs at either time point. However, within the opioid-exposed group, there was a significant increase in infant HCCs across the two time points. CONCLUSION: This pilot study describes our experience with the measurement of HCCs in opioid-exposed mother-infant dyads. KEY POINTS: · Maternal stress impacts fetal and child health.. · Many stressors in pregnant women with opioid use disorder.. · Hair cortisol may be a useful stress biomarker..


Subject(s)
Biomarkers , Hair , Hydrocortisone , Opioid-Related Disorders , Stress, Psychological , Humans , Hydrocortisone/analysis , Hydrocortisone/metabolism , Female , Hair/chemistry , Pregnancy , Prospective Studies , Adult , Pilot Projects , Biomarkers/analysis , Biomarkers/metabolism , Infant, Newborn , Stress, Psychological/metabolism , Infant , Pregnancy Complications , Prenatal Exposure Delayed Effects , Case-Control Studies , Young Adult , Male , Analgesics, Opioid/adverse effects
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