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Hellenic J Cardiol ; 65: 15-18, 2022.
Article in English | MEDLINE | ID: mdl-35227852

ABSTRACT

OBJECTIVE: The correction of functional mitral regurgitation (FMR) with transcatheter edge-to-edge repair (TEER) can favorably affect patients' hemodynamic profile. However, the procedure requires inter-atrial trans-septal access and the hemodynamic relevance of the residual iatrogenic atrium septal defect (iASD) is still debated. This study aimed at investigating the hemodynamic modifications during TEER with MitraClip, before and after the iASD creation, in patients with heart failure with reduced ejection fraction (HFrEF) and severe FMR. METHODS: Thirty-nine HFrEF patients with 3+ or 4+/4+ FMR were included. Right heart catheterization was performed at baseline after general anesthesia induction and at the end of TEER, both before and after removing the device guiding catheter. RESULTS: Compared with baseline, MitraClip positioning was followed by a significant immediate improvement in cardiac output (respectively: 3.36 vs 5.05 ml/min), pulmonary artery wedge pressure (23.7 vs 18.2 mmHg), mean pulmonary artery pressure (34.4 vs 27.7 mmHg) and pulmonary vascular resistance (3.6 vs 2.2 Wood Units) (all p < 0.001). No further significant modifications occurred after removing the device guiding catheter. CONCLUSIONS: Our data suggest that the acute hemodynamic modifications after TEER are not influenced by the induction of iASD in patients with FMR.


Subject(s)
Heart Failure , Heart Septal Defects, Atrial , Heart Valve Prosthesis Implantation , Mitral Valve Insufficiency , Cardiac Catheterization/methods , Heart Septal Defects, Atrial/complications , Heart Septal Defects, Atrial/surgery , Hemodynamics , Humans , Iatrogenic Disease , Mitral Valve/surgery , Mitral Valve Insufficiency/surgery , Stroke Volume , Treatment Outcome
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