Massive Pulmonary Embolus Following a Hemorrhagic Stroke: A Thrombolysis Therapy Dilemma.

Pulmonary embolism varies in presentation with factors such as embolus size and pre-existing comorbidities contributing significantly. Despite the availability of several options to treat pulmonary embolism, these options significantly decrease when a massive pulmonary embolism causes a cardiac arrest in the setting of a recent hemorrhage thalamic stroke. We reviewed the current literature and presented a case report. In addition, we presented seven cases of pulmonary embolus where thrombolysis was used despite an absolute contraindication to thrombolysis, and the patients had successful outcomes.

A Review of Four Practice Guidelines of Inflammatory Bowel Disease.

Inflammatory bowel disease (IBD) is a term that encompasses conditions characterized by chronic inflammation of the gastrointestinal tract (GIT). It includes Crohn's disease and ulcerative colitis. Major scientific organizations interested in gastrointestinal systems or GIT-focused organizations worldwide release guidelines for diagnosing, classifying, managing, and treating IBD. However, there are subtle differences among each of these guidelines. This review evaluates four evidence-based guidelines in the management of IBD and seeks to highlight the differences and similarities between them. The main differences in the evaluated guidelines were in diagnosis and treatment recommendations. The diagnosing recommendations were comparable amongst the four guidelines; however, some were more specific about limiting the number of interventions necessary to confirm a diagnosis. Regarding treatment options, each guideline had clear suggestions about what was considered ideal. Although the treatment options were identical, the main differences existed in the recommended diets and initial therapy in patients with moderate disease. Clinical practice guidelines (CPGs) recommend evidence-based practice from opinion leaders in clinical decision-making. Rather than dictating a one-size-fits-all approach in IBD management, reviewing various guidelines can enhance the cross-pollination of ideas amongst clinicians to improve decision-making. Clearly describing and appraising evidence-based reasoning for scientific recommendations remain driving factors for quality patient care. The effectiveness of CPGs in improving health and the complexities of their formation requires constant review to maximize constructive criticisms and explore possible improvements.