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Med Chem ; 5(3): 237-41, 2009 May.
Article in English | MEDLINE | ID: mdl-19442213

ABSTRACT

After administration of various amounts of pralidoxime to rats, the levels in serum, brain and cerebrospinal fluid (CSF) were measured using capillary zone electrophoresis (CZE). The calibration curves were established using spiked samples. The calibration covers the ranges from 0.3 - 200 microg/mL, 0.3 - 7 microg/mL and 0.1 - 7 microg/mL for serum, brain and CSF, respectively. The CZE measurement opens the way to the fast and reliable determination of pyridinium aldoxime concentrations in serum, cerebrospinal fluid and brain, thereby monitoring blood-brain and blood-CSF penetration of pyridinium aldoxime-type antidotes clinically used in organophosphate poisoning.


Subject(s)
Antidotes/analysis , Brain Chemistry , Pralidoxime Compounds/blood , Pralidoxime Compounds/cerebrospinal fluid , Animals , Antidotes/pharmacokinetics , Blood-Brain Barrier/metabolism , Dose-Response Relationship, Drug , Electrophoresis, Capillary , Male , Pralidoxime Compounds/analysis , Pralidoxime Compounds/pharmacokinetics , Rats , Rats, Wistar
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