ABSTRACT
The authors analyze the literature publications and the results of their original investigations concerning the application of the propolis-based pharmacological products for the treatment of acute and chronic diseases of the upper respiratory tract and ears. The desirability of the more extensive application of the propolis-containing medicines in the routine otorhinolaryngological practice is emphasized bearing in mind their numerous biological effects including antibiotic, anti-inflammatory, immunostimulating, anti-oxidative, anesthetic, and cytostatic actions.
Subject(s)
Otorhinolaryngologic Diseases/therapy , Propolis/pharmacology , Anti-Infective Agents/pharmacology , Antioxidants/pharmacology , Drug Administration Routes , Humans , Immunization/methods , Otorhinolaryngologic Diseases/diagnosis , Otorhinolaryngologic Diseases/immunology , Treatment OutcomeABSTRACT
Reactions induced by venom from the scorpion Buthus eupeus and by toxin of the venom have been studied on isolated organs and tissues as well as on intact body. It has been shown that substances interfering with the conduction of nerve excitation, with the mediator storage and interaction of the latter with synaptic receptors prevent the reactions induced by the venom and toxin, whereas ganglion-blocking agents do not affect these reactions. The catecholamine content in rat blood plasma has been found to be increased. It is assumed that the venom and toxin that affect the postganglionic nerve terminals release mediator acetylcholine and noradrenaline.
