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Adv Healthc Mater ; 3(9): 1426-9, 2014 Sep.
Article in English | MEDLINE | ID: mdl-24652761

ABSTRACT

Here, the modulation of enzyme activity is presented by protein-imprinted nanoparticles produced using a solid-phase approach. Using trypsin as target, binding of the nanoparticles to the enzyme results in its inhibition or in stabilization, depending on the orientation of the immobilized enzyme used during imprinting.


Subject(s)
Enzymes, Immobilized/metabolism , Molecular Imprinting/methods , Nanoparticles/chemistry , Trypsin/metabolism , Biocompatible Materials/chemical synthesis , Biocompatible Materials/chemistry , Biocompatible Materials/metabolism , Enzymes, Immobilized/chemistry , Nanotechnology/methods , Surface Plasmon Resonance , Trypsin/chemistry
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