Investigating possible correlation between condylar asymmetry and clinical dysfunction indices in patients with temporomandibular dysfunction using Cone-beam computed tomographic.

PURPOSE: Temporomandibular disorder (TMD) is a common problem in modern societies. Causes of TMD, as a consequence of condylar asymmetry index (CAI), are still a subject of controversy. The aim of the present study was to determine the possible correlations between the degree of condylar asymmetry and clinical dysfunction indices. MATERIALS AND METHODS: In this cross-sectional study, we used the Habets method to measure the CAI in 42 TMD patients. The participants' age and sex were matched in the control group. Patients were divided into mild, moderate and severe dysfunction groups based on Helkimo's clinical Di. The data were analyzed using Mann-Whitney U and Kruskal-Wallis tests. Also, the study attempted to assess the possibility of correlation between age and CAI. RESULTS: The CAI values of TMD patients were significantly higher than those of the control group (P = 0.001). However, CAI was not significantly different among TMD patients with different dysfunction index. There was no significant correlation between CAI and age (Spearman r = 0.655, P = 0.23). CONCLUSION: Based on the findings of the present study, patients with condylar asymmetry index are more susceptible to TMD. However, degree of the condylar asymmetry is not a criterion for TMD signs and symptoms.

Comparison of the regenerative effect of adipose-derived stem cells, fibrin glue scaffold, and autologous bone graft in experimental mandibular defect in rabbit.

BACKGROUND/AIMS: One of the main concerns for maxillofacial and orthopedic surgeons is finding a method to improve regeneration of large craniofacial bone defects. The aim of this study was to investigate the healing and regenerative effects of fibrin glue associated with adipose-derived stem cells (ADSCs) and fibrin glue scaffold alone with autologous bone grafts in experimental mandibular defects of the rabbit. METHODS: Bilateral uni-cortical osteotomies were performed in the mandible of 20 male Dutch rabbits. The animals were randomly divided into 2 equal groups. In one group, the defect on the right side was treated by fibrin glue associated with ADSCs and the defect on the other side remained as the control. In another group, the defect on the right side was treated with fibrin glue and on the left side with autologous bone graft. After 28 and 56 days, five rabbits from each group were evaluated by computed tomography (CT) and histopathological examinations. RESULTS: Coronal CT showed a remarkable reconstruction of cortical bone in the fibrin glue associated with ADSCs group at 28 and 56 days post-surgery. Histopathologically, new cortical bony bridge formation was seen increasingly in the fibrin glue, fibrin glue associated with ADSCs, and autologous bone graft groups after 28 days. Statistical analysis of the thickness of new cortical bone in the treatment versus control groups showed a significant difference between fibrin glue alone and fibrin glue associated with ADSCs groups (P = 0.02). No significant difference was found between the fibrin glue associated with ADSCs and the autologous bone graft groups (P > 0.05). CONCLUSIONS: The healing process had a significant increase in the thickness of new cortical bone when fibrin glue scaffold associated with ADSCs was used.

Tissue Engineering in Maxillary Bone Defects.

BACKGROUND: Restoration of craniofacial bone defects has been a concern for oral and maxillofacial surgeons. In this study, the healing effect of fibrin glue scaffold was compared with autologous bone graft in mandibular defects of rabbit. METHODS: Bilateral unicortical osteotomy was performed in the diastema region of 10 male Dutch rabbits. The subjects were randomly divided into 2 equal groups. The mandibular defect on the right side was treated with fibrin glue scaffold and the defect on the left side with autologous bone graft provided from iliac crest. After 4 and 8 weeks, five rabbits from each group were sacrificed and the defects were evaluated morphologically, by coronal computed tomography scanning (CT-scan) and by histological examinations. RESULTS: The healing effect of fibrin glue scaffold and autologous bone graft was similar with appropriate osteogenesis in comparison to the control group. CONCLUSION: Using fibrin glue can be a non-invasive treatment of choice in mandibular defects and maxillofacial surgeries when compared with autologous bone graft.

Comparison of the Pharyngeal Airway Volume between Non-Syndromic Unilateral Cleft Palate and Normal Individuals Using Cone Beam Computed Tomography.

STATEMENT OF THE PROBLEM: Individuals with cleft lip and cleft palate mostly have airway problems. Introduction of cone beam computed tomography (CBCT) and imaging software has provided the opportunity for a more precisely evaluating 3D volume of the airway. PURPOSE: The purpose of this study was to analyze and compare 3D the pharyngeal airway volumes of cleft palate patients with normal individuals using CBCT. MATERIALS AND METHOD: 30 complete cleft palate patients were selected from the Department of Orthodontics; Dental University (Shiraz, Iran) who had CBCT scans of the head. The control group included 30 individuals with Class I angle occlusion who were matched for age and gender with the experimental group. ITK-SNAP 2.4.0 PC software was used to build 3D models of the airways for the subjects and measuring airway volumes. The statistical analyses were performed using SPSS software (version 19). Mann-Whitney test was adopted with p< 0.05 as statistical significance. RESULTS: The average volume of the pharyngeal airway of cleft group was 18.6 cm3, with mean volumes of 6.8 cm3 for the superior component and 11.3 cm3 for the inferior component. The total and superior airway volume of cleft group were significantly lower than non-cleft groups (p= 0.008, p= 0.00, respectively) but the inferior airway volumes were not significantly different between the cleft and non-cleft groups. There was a significant and positive correlation between superior airway volume and inferior airway volume in cleft palate patients (r=+0.786, p< 0.001) and control group (r=+0.575, p= 0.001). CONCLUSION: 3D analysis showed that the nasal and total airway was restricted in individuals with cleft palate but the inferior airway was not compromised in these individuals. This would be a crucial data to be considered for surgeons during surgical planning.

Correlation of radiographic features and treatments with the frequency of recurrence in odontogenic keratocysts of the mandible.

PURPOSE: Odontogenic keratocysts (OKCs) have high recurrence potential. The aim of the study is to evaluate the correlation of radiographic features and treatments with the frequency of recurrence in OKCs in the mandible. MATERIALS AND METHODS: This is a cohort retrospective study. The size of the lesions was measured on orthopantomography. Radiographic features (unilocular or multilocular), location, treatment type (enucleation or marsupialization), follow-up time, age, and sex were variable factors. Subjects were studied in 2 groups: a recurrence group and a nonrecurrence group. The radiographic size was considered to be a predictive factor, and the frequency of recurrence was an outcome of the study. An independent t-test and chi-squared test were used to compare variables between recurrence and nonrecurrence groups. Cox regression was applied to the time effect evaluation of the lesion's size and recurrence. A receiver operating characteristic test was used to find a cutoff point for recurrence in the size of radiographic views. RESULTS: Ninety-one subjects were studied. Radiographic features and sizes were different between the 2 groups. The frequency of recurrent lesions was significantly different in various sites of the mandible. Cox regression demonstrated a positive effect of follow-up time on the risk of recurrence. In a 1-year increase in the follow-up time, the recurrence rate increased 1.07 times. An analysis of the data showed a positive relationship between radiographic size and recurrence rate. A 1-cm increase in the lesion's size increased the recurrence rate 1.67 times. A receiver operating characteristic test demonstrated 5.25 cm as a cutoff point in radiographic size; the radiographic size sensitivity was 88.5% (69.8%-97.4%), and specificity was 93.8% (85%-98.3%) for recurrence lesions. Lesions that were 5.25 cm or more on radiographic views had a significant relationship with recurrence rate (P < 0.05). The positive predictive value was 85.2% (65.4%-95.1%), and the negative predictive value was 95.3% (86%-98.8%). CONCLUSIONS: The radiographic size may be a predictive factor for the frequency of recurrence lesions in OKCs. Primary multilocular lesions had a greater probability for recurrence than unilocular lesions.