Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 9 de 9
Filter
Add more filters










Database
Publication year range
1.
Neurol Clin Neurophysiol ; 2004: 43, 2004 Nov 30.
Article in English | MEDLINE | ID: mdl-16012686

ABSTRACT

We propose a novel classification method based on the Bayes rule to utilize the magnetocardiogram (MCG) in noninvasive mass screening. The cardiac excitation is directly tracked by maps of the MCG field generated by myocardial excitation current through the excited wave front. To adopt the characteristics of the excited wave fronts as a parameter for the Bayes theorem, we developed a parameterization procedure that consists of a two-dimensional wavelet approximation and a cluster analysis of magnetic field maps. With the parameter determined by this procedure, the probability of a subject to belong to a disease group or to the normal group is estimated by the Bayes theorem. The subject is classified into the group of the highest probability. We applied the proposed method to ST-T period of MCG data of 6 old myocardial infarction (OMI) patients and 15 normal controls. The method showed sensitivity of 83%; specificity, 100%; positive predictive value, 100%; and negative predictive value, 94% in the classification of OMI patients and normal controls. The processing time is less than 5 seconds per one subject. It suggests a possible application of the proposed method in mass screening of abnormal MCG patterns.


Subject(s)
Electrocardiography/methods , Electromagnetic Fields , Myocardial Infarction/classification , Myocardial Infarction/physiopathology , Bayes Theorem , Humans
2.
Nihon Jinzo Gakkai Shi ; 43(1): 35-8, 2001.
Article in Japanese | MEDLINE | ID: mdl-11218316

ABSTRACT

Congenital nephrogenic diabetes insipidus is a rare disorder in which the kidney is insensitive to the antidiuretic hormone, vasopressin. In most cases, a mutation in the vasopressin type 2(V2) receptor gene is the genetic cause of the disease. So far, few cases of congenital nephrogenic diabetes insipidus with hypertension have been reported. We report one male case of congenital nephrogenic diabetes insipidus accompanied by hypertension. The patient was a 24-year-old man who had suffered from polyuria and polydipsia since infancy and had been found to have hypertension at about 16 years. He was admitted to hospital in May 2000 for investigation of polyuria and hypertension with a high plasma level of renin activity of 10.4 ng/ml/hr. On physical examination, the blood pressure was 150/90 mmHg and the daily urinary output was 18.5 l. There was no change in urine volume and urine osmolality after an intramascular injection of vasopressin and water deprivation. The blood pressure and plasma renin activity were increased from 127/73 mmHg to 146/87 mmHg and from 4.9 ng/ml/hr to 6.1 ng/ml/hr, respectively, by a 4-hour dehydration test. He was found to have a C-to-T transition at nucleotide position 675 by sequencing analysis of the V2 receptor gene. After administration of hydrochlorothiazide, both the blood pressure and urine volume were reduced. Consequently, it was suggested that activation of the renin-angiotensin system by dehydration, at least in part, contributed to high blood pressure in this case.


Subject(s)
Diabetes Insipidus, Nephrogenic/diagnosis , Hypertension, Renal/complications , Adult , Diabetes Insipidus, Nephrogenic/complications , Humans , Male , Vasopressins/genetics
3.
Br J Pharmacol ; 117(6): 1334-40, 1996 Mar.
Article in English | MEDLINE | ID: mdl-8882633

ABSTRACT

1. To test the hypothesis that protein kinase C (PKC) is involved in the inhibitory actions of lipoxin A4 (LXA4) on second messenger generation, we studied the effects of LXA4 on PKC in human neutrophils and on leukotriene B4 (LTB4)-stimulated inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) generation. 2. LXA4, 1 microM, caused a fall in cytosolic PKC-dependent histone phosphorylating activity to 23.5% of basal levels. 3. LXA4, caused an increase in particulate PKC-dependent histone phosphorylating activity with a bell-shaped dose-response fashion; maximal stimulation was observed at 10 nM LXA4. 4. Western blot analysis with affinity-purified antibodies to alpha- and beta-PKC showed that only the beta-PKC isotype was translocated by LXA4. 5. LXA4 inhibited LTB4-stimulated Ins(1,4,5)P3 generation in a bell-shaped fashion with maximal inhibition at 1 nM LXA4. The observed inhibition was dose-dependently removed by pre-incubation with a PKC inhibitor (Ro-31-8220). 6. These results show that LXA4 activates PKC in whole cells and supports a role for PKC activation in the inhibitory action of LXA4 on LTB4-induced Ins(1,4,5)P3 generation. 7. LXA4 (1-1000 nM) pre-incubation did not affect specific binding of [3H]-LTB4 to neutrophils. Thus, the inhibitory effect of LXA4 on LTB4-stimulated Ins(1,4,5)P3 generation could not be attributed to an effect on LTB4 receptors.


Subject(s)
Hydroxyeicosatetraenoic Acids/pharmacology , Inositol 1,4,5-Trisphosphate/biosynthesis , Leukotriene B4/pharmacology , Lipoxins , Neutrophils/drug effects , Protein Kinase C/metabolism , Receptors, Leukotriene B4/drug effects , Blotting, Western , Dose-Response Relationship, Drug , Drug Antagonism , Enzyme Inhibitors/pharmacology , Humans , Indoles/pharmacology , Leukotriene B4/antagonists & inhibitors , Neutrophils/metabolism , Protein Kinase C/antagonists & inhibitors , Receptors, Leukotriene B4/metabolism
4.
J Psychiatr Res ; 26(1): 77-84, 1992 Jan.
Article in English | MEDLINE | ID: mdl-1560411

ABSTRACT

The sequestration of [3H]spiperone by lymphocytes was studied in preserved cells obtained from 22 schizophrenic subjects and 40 of their relatives, and the results were compared with those obtained from 25 healthy control subjects. Mean displaceable sequestration values, obtained from measurements made at a single radioligand concentration (1nM) which optimised the relative contribution of "high affinity" sequestration, were found to be similar for all groups of subjects. Furthermore, displaceable spiperone sequestration was abnormally high in only a small proportion of the schizophrenics (13.6%) and their relatives (5%). There was no evidence that either exposure to neuroleptic medication or duration of illness had an effect on sequestration values. The results suggest that, at least until the required experimental conditions are better established, [3H]spiperone sequestration by lymphocytes does not offer a useful vulnerability marker for schizophrenia.


Subject(s)
Lymphocytes/metabolism , Receptors, Dopamine/metabolism , Schizophrenia/genetics , Schizophrenic Psychology , Spiperone/pharmacokinetics , Adolescent , Adult , Aged , Binding, Competitive/physiology , Female , Humans , Male , Middle Aged , Receptors, Dopamine/genetics , Schizophrenia/blood , Schizophrenia/diagnosis
7.
Psychol Med ; 16(2): 297-305, 1986 May.
Article in English | MEDLINE | ID: mdl-3726005

ABSTRACT

The nutritional status of 23 severely demented patients was compared with that of 23 similarly aged controls in the community. A 3-day weighed intake on all subjects showed lower mean intakes of energy, protein, ascorbic acid and nicotinic acid in the mean intakes of energy, protein, ascorbic acid and nicotinic acid in the patient group. This group had lower levels of plasma ascorbic acid and red cell folate and of urinary N-methylnicotinamide excretion relative to creatinine. Over a third of both controls and patients had evidence of thiamin deficiency, as judged by a raised percentage erythrocyte transketolase activity. An earlier finding in patients with senile dementia of reduced fasting plasma concentrations of tryptophan was confirmed for total and protein bound fractions. With the possible exception of ascorbic acid, the data could not be explained satisfactorily in terms of intake. It is suggested that the association between the phenomena of aging, senile dementia and nutritional status merits further investigation.


Subject(s)
Deficiency Diseases/complications , Dementia/blood , Tryptophan/blood , Aged , Ascorbic Acid Deficiency/complications , Brain/metabolism , Deficiency Diseases/blood , Dietary Proteins/administration & dosage , Energy Intake , Energy Metabolism , Female , Folic Acid Deficiency/complications , Humans , Male , Nutritional Requirements , Protein Binding , Serotonin/deficiency , Vitamin D Deficiency/complications
SELECTION OF CITATIONS
SEARCH DETAIL
...