The effect of conjugated estrogens and estriol succinate on fibrinolysis: a clinical correlation in patients with uterine bleeding

The inhibitory effect of conjugated estrogens and estriol succinate on fibrinolysis was demonstrated in normal subjects and in patients with uterine bleeding by a delay in onset and or completion of clot lysis using a modification of the fibrinolysin test of Stefanini and Damashek. Clot lysis was accelerated in normal subjects by intravenous adrenalin at a dose of 0.1 mcg per kilogram body weight. Control of uterine bleeding was correlated with the experimental data. (Summary)