[Dependence of immune and biochemical homeostasis mechanisms on lead accumulation in the body (experimental study)]. / Zavisimost' izmeneniia immunnykh i biokhimicheskikh mekhanizmov podderzhaniia gomeostaza ot material'noi kumuliatsii svintsa v organizme (éksperimental'noe issledovanie).

It was established in experiments on rats that lead accumulation in organism caused by 1/100 DL50 lead acetate repeated injections connected with Ca2+ competition forcing out from bone tissue and taking it out from blood. It was accompanied by homeostasis maintenance physiologic mechanisms disturbance and lead toxic influence realization in liver, cordial, brain tissues, as well as immune toxic influence display on neutrophiles, periphery blood lymphocytes and on spleen lymphocytes.

[The influence of the optical irradiation of natural and artificial sources on humans]. / Vliianie opticheskogo izlucheniia estestvennykh i iskusstvennykh istochnikov na cheloveka.

The authors studied parameters of human natural insolation in relationships with season and functioning of main body systems. The functioning rhythms appeared to depend on natural saturation with optic energy. Regulation of light energy emitted by artificial sources requires consideration of natural background insolation in various seasons.

[The specific and nonspecific mechanisms of the formation of adaptive-compensatory reactions during extreme exposure to heat]. / Spetsificheskie i nespetsificheskie mekhanizmy formirovaniia adaptatsionno-kompensatornykh reaktsii pri ékstremal'nom vozdeistvii tepla.

A total of 250 white male rats were subjected to 48 hours experiment in order to study specific (functional state of thermoregulation, heart muscle, brain cortex) and nonspecific (ration of free radical oxidation activity to antioxidant system activity) mechanisms of adaptational and compensatory reactions, those of alteration and restoration after single critical heating (temperature 41.5 +/- 0.5 degrees C) during 1 hour. The animals appeared to develop no adaptation to the studied heating level, that was demonstrated by assessment of specific regulatory systems and by studies of free radical oxidation and antioxidant system activities.

[The blood serum biochemical indices as criteria for assessing the action on the body of industrial enzyme preparations]. / Biokhimicheskie pokazateli syvorotki krovi kak kriterii otsenki deistviia na organizm promyshlennykh fermentnykh preparatov.

Workers of the enzyme industry showed changes of blood biochemistry advancing with the length of contacts with enzyme drugs as evidenced by inhibition of cholinesterase, activation of phosphatase and antitryptic blood serum activity. Increased content of blood histamine in these workers evidences sensibilizations to the enzymes, while simultaneous activation of monoaminoxidase should be considered as a compensatory reaction of the body.

[Changes in the serum enzymo- and proteinograms of workers in enzyme production suffering from skin diseases (the validation of the diagnosis and of the therapeutic-preventive measures)]. / Izmenenie syvorotochnykh fermento- i proteinogramm u rabochikh fermentnogo proizvodstva, stradaiushchikh zabolevaniiami kozhi (k obosnovaniiu diagnostiki i lechebno-profilakticheskikh meropriiatii).

Clinical and epidemiologic examinations of 260 workers engaged in enzyme production revealed the structure of skin disease incidence: mycoses--31%, atopic dermatitis--19%, contact dermatitis--9%, allergic, dermatitis--5%. The majority of these skin diseases were associated with hyperphosphatemia and monoaminoxidase (MAO) depression. Changes of alkaline phosphatase and MAO activities, serum albumins and gamma-globulins may be considered as sensitive markers of disease.

[Activity of serum enzymes in workers in the enzyme production industry]. / Aktivnost' syvorotochnykh fermentov u rabochikh proizvodstva fermentnykh preparatov.

Unfavorable industrial factors in the production of enzyme preparations (enzyme dusts, microorganisms-producers) cause changes in the activity of a number of enzymes in workers' blood serum. Degree frequency and direction of enzyme shifts depend on the purity of enzyme preparations, degree of contact with them, workers' length of service and health status. The analysis of the obtained results enables us to recommend a determination of cholinesterase activity, acid phosphatase and lactate-dehydrogenase as indicators for a hygienic assessment of the effect of enzyme preparations and diagnosis of body pathogenic changes.