[Methods of advanced purification-the challenge for biosynthetic antibiotics industry]. / Procedee de purificare avansata--provocare pentru industria antibioticelor de biosinteza.

Reactive extraction, permeation through liquid membranes and direct extraction are some of the new techniques applied for separation and advanced purification of biosynthetic antibiotics. Compared with the conventional separation techniques, the main advantages of these extraction methods are: high separation efficiency, the avoidance of antibiotics chemical and thermal inactivation, high purity of obtained antibiotics. Furthermore, using reactive extraction or permeation through liquid membrane, the antibiotics can be selective separated from their biosynthesis precursors or from the secondary biosynthetic compounds. This paper is a review on separation of Penicillins and Erythromycin by means of these extraction techniques, being underlined their advantages, applications and problems concerning the separation process scale-up.

On hypotensive action of some imidazoline derivatives of sulphonamidated aryloxyalkylcarboxylic acids.

New imidazolines derived from sulphonamidated aryloxyalkylcarboxylic acids have been tested for their antihypertensive action and toxicity. The obtained results attest a remarkable biological action, low toxicity and a good absorption in oral administration.

[The specific effects of new phenoxyacetic acid derivatives at the cellular membrane level]. / Efecte specifice ale unor noi derivati ai acidului fenoxiacetic la nivelul membranei celulare.

Substances ASFA-2 and ASFA-4, new derivatives of phenoxyacetic acid, induce, in normal conditions, the hyperpolarization of the striated muscle fibre membrane, inhibition the depolarization due to the absence of external Ca2+, the restoration of membrane potential of the liver cells poisoned with ally alcohol and the change of redox potential of the environment. It results that these substances have important pharmacological properties--influence upon the membrane potential and cellular excitability, membrane stabilization, redox modulation and hepatic protection--that can be useful in therapy.